Greener synthesis of spirooxindole in deep eutectic solvent

Environmental Impact of Ionic Liquids: Recent Advances in (Eco)toxicology and (Bio)degradability

“…Furthermore, new generations of salts, such as deep eutectic solvents (DESs) show good performance in chemical reactions. The synthesis of DESs simply involves mixing two cheap components with low environmental impact together to form a eutectic mixture without the need for any additional solvents . Additionally, ILs have the advantage of solvent recovery and reducing waste generation and emission to the environment…”

Magnetically separable g‐C3N4 hybrid nanocomposite: Highly efficient and eco‐friendly recyclable catalyst for one‐pot synthesis of α‐aminonitriles

“…In continuation of our efforts to develop environmentally benign solvents and catalysts for useful organic transformations, herein, we report a very effective and green procedure for the one‐pot synthesis of diverse racemic α‐aminonitriles in excellent yields using magnetic g‐C 3 N 4 as an inexpensive and environmentally benign catalyst under mild conditions. The presented method not only uses a cost‐effective and magnetically recoverable catalyst and environmentally benign solvent, but also experimentally safe and easy‐to‐handle TMSCN as reagent.…”

Synthesis of spiro-fused heterocyclic scaffolds through multicomponent reactions involving isatin

“…162 In another study, glycerol as a biodegradable and reusable promoting medium was applied under catalyst-free conditions. 163 This reaction was also conducted under catalyst-free condition in deep eutectic solvent (DES based choline chloride) 164 or under catalyst-free conditions in DMSO at 70 °C. 165 Elinson's group reported thermal non-catalytic reaction in water or alcohols in high yields.…”