The greenhouse climate is a non-linear system that contains multiple inputs (predictors) and multiple outputs (responses). This project aimed to provide a solution, aided by artificial intelligence, to the issue of variations in time, input and output factors in a greenhouse internal climate that can adversely affect tomato seedlings. Machine learning Methodologies such as fuzzy inference and neural networks have been applied to mimic idealistic behavior. This paper proposes an adaptive system based on artificial neural networks technique embedded with fuzzy logic technique calls Adaptive Neuro Fuzzy Inference System (ANFIS) to predict air humidity, air temperature, internal radiation, and CO2 concentration while the seeds grow, in order to produce favorable greenhouse climate conditions. The input parameters include ten meteorological and control actuators that majorly influence tomato plants during their growth process in the greenhouse climate. This discussion revolves around a linguistic ANFIS model that will operate during the 48 days that it takes for the seedlings to grow. It will provide estimates of the greenhouse climate using meteorological data along with control actuators rooted in trained neural networks with back propagation optimization algorithm, and 500 iterations of the least square algorithm. Simulations have revealed the efficiency of this model.