Greenspace and mortality in the U.K. Biobank: Longitudinal cohort analysis of socio-economic, environmental, and biomarker pathways

Wan, Shiyu; Rojas-Rueda, David; Pretty, Jules; Roscoe, Charlotte; James, Peter; Ji, John S.

doi:10.1016/j.ssmph.2022.101194

Cited by 12 publications

(6 citation statements)

References 69 publications

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“…One possible explanation is that the noxious gases and particulate matter generated during tobacco combustion may cause airflow obstruction, which is a primary cause of depression owing to impaired lung function [ 33 ]. Furthermore, the deleterious effects of poor lung function on subsequent depressive symptoms were pronounced in populations with low SES, which was congruent with a previous survey that concluded that individuals with low SES experience a reduction in the beneficial impact of improved lung function on overall health [ 34 ].…”

Section: Discussionsupporting

confidence: 89%

Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants

Hu,

Liu,

Jia

2024

BMC Med

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Background Lung health is increasingly recognized as an essential factor in mental health. However, prospective evidence on lung function with incident depression remains to be determined. The study aimed to examine the prospective association between impaired lung function and incident depression and the underlying biological mechanisms. Methods This prospective cohort study comprised 280,032 non-depressed individuals with valid lung function measurements from the UK Biobank. Lung function was assessed through the forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV1). Cox proportional hazard models were applied to estimate the associations between lung function and incident depression. Mediation analyses were fitted to investigate the potential mediating role of biomarkers and metabolites in the association. Results A total of 9514 participants (3.4%) developed depression during a median follow-up of 13.91 years. Individuals in the highest quartile had a lower risk of depression (FVC % predicted: HR = 0.880, 95% CI = 0.830–0.933; FEV1% predicted: HR = 0.854, 95% CI = 0.805–0.905) compared with those in the lowest quartile of the lung function indices. Additionally, the restricted cubic splines suggested lung function indices had reversed J-shaped associations with incident depression (nonlinear P < 0.05 for FVC % predicted and FEV1% predicted). Impaired lung function yielded similar risk estimates (HR = 1.124, 95% CI = 1.074–1.176). Biomarkers involving systemic inflammation, erythrocytes, and liver and renal function may be potential mediators in the lung function-depression association. Conclusions This study revealed that the higher risk of developing depression was associated with impaired lung function. Also, the association might be partially mediated by biomarkers including systemic inflammation, erythrocytes, and liver and renal function, though these mediation findings should be interpreted with caution due to potential temporal ambiguity.

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Section: Discussionsupporting

confidence: 89%

Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants

Hu,

Liu,

Jia

2024

BMC Med

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“…Physical activity was divided into regular/not regular, with the former category defined as sustaining vigorous exercise ≥75 min/week or moderate exercise for ≥150 min/week (or an equivalent combination), or moderate exercise ≥5 days/week or vigorous exercise ≥1 day/week 32. As an indicator of mental health, the neuroticism score was calculated using the Eysenck Personality Questionnaire–Revised Short Form33 (online supplemental material text S2).…”

Section: Methodsmentioning

confidence: 99%

Associations of residential greenness with bone mineral density and osteoporosis: the modifying effect of genetic susceptibility

Tan,

Tang,

Guo

et al. 2024

Ann Rheum Dis

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ObjectivesTo investigate the associations of residential greenness with bone mineral density and incident osteoporosis, and further evaluate the potential modifying effect of genetic susceptibility.MethodsWe used the Normalised Difference Vegetation Index (NDVI) at various buffer distances, including 300 m (NDVI300m), 500 m (NDVI500m), 1000 m (NDVI1000m) and 1500 m (NDVI1500m), to serve as indicators of greenness. We fitted linear regression, logistic regression and Cox proportional hazard models to assess the associations of residential greenness with estimated bone mineral density (eBMD), prevalent osteoporosis and incident osteoporosis, respectively. With the Polygenic Risk Score (PRS) for osteoporosis, we further assessed the joint effects of genetic risk and greenness on the risk of osteoporosis. We conducted causal mediation analyses to explore potential mediators.ResultsEach IQR increase in NDVI300mwas associated with 0.0007 (95% CI 0.0002 to 0.0013) increase in eBMD, 6% lower risk of prevalent osteoporosis (OR 0.94; 95% CI 0.92 to 0.97) and 5% lower risk of incident osteoporosis (HR 0.95; 95% CI 0.93 to 0.98). The joint effects of greenness and PRS on the risk of osteoporosis displayed a clear dose-response pattern. Compared with individuals exposed to low NDVI levels and high genetic risk, those exposed to high NDVI levels and low genetic risk had a 56% (95% CI 51% to 61%) lower risk of osteoporosis. The primary mediators in the association between greenness and incident osteoporosis were identified as PM2.5and NO2.ConclusionsResidential greenness was associated with higher bone mineral density and decreased risk of incident osteoporosis.

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“…The field of urban environmental studies has highlighted the importance of natural elements in urban infrastructure for more livable urban environments [17][18][19][20]. Research and subjective experience strongly support the idea that nature has net positive health benefits for humans [21][22][23][24]. These basic studies greatly affirm the importance of studying the relationship between nature and human health.…”

Section: Introductionmentioning

confidence: 93%

Effect of Nature Space on Enhancing Humans’ Health and Well-Being: An Integrative Narrative Review

Zhang,

Ye,

Yang

et al. 2024

Forests

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With the progress of science and technology, humans’ ability to transform and create has been greatly enhanced, but so have the physical and mental ailments associated with environmental degradation and urbanization. Human survival and health are strongly linked to nature, and there is growing evidence that exposure to nature promotes health and well-being. However, there is currently a lack of synthesis among empirical studies on these aspects for the findings to be sufficient for informing public health strategies and social policy. Here, following basic guidelines for systematic review and meta-analysis, we searched PubMed, Web of Science, ScienceDirect, and Scopus databases in January 2023. The results of our search and analysis show that nature can improve people’s health and well-being from two aspects: physical (reduces CVDs, increases immunity, improves autonomic nervous system function, and improves sleep quality) and psychological (restores attention, improves mood, reduces stress, and improves cognitive development). The ways in which people derive health from nature are varied, and tailored, personalized, symptom-specific exposure can further increase the health benefits. More importantly, it seems that people can gain the health benefits of nature by only being exposed to it for a short time. We incorporate the existing scientific evidence in our review and develop a new heuristic point of view on the necessity of exposure to natural environments for the health of individuals.

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Greenspace and mortality in the U.K. Biobank: Longitudinal cohort analysis of socio-economic, environmental, and biomarker pathways

Cited by 12 publications

References 69 publications

Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants

Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants

Associations of residential greenness with bone mineral density and osteoporosis: the modifying effect of genetic susceptibility

Effect of Nature Space on Enhancing Humans’ Health and Well-Being: An Integrative Narrative Review

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