Background: Despite the importance of health grey literature, there is not a comprehensive information system for managing these valuable resources in Iran.
Objectives:This study aimed at identifying the barriers to and facilitators of implementing a comprehensive national information system for health grey literature.
Material and method:This study applied the qualitative research method.Semi-structured interviews were conducted among 19 experts in related fields. A qualitative content analysis was used to analyze the data in MAXQDA. The data were codified and revised constantly and classified in some selected main and sub-categories based on their relative similarities and differences.Results: Data analysis identified some barriers to the implementation of an information system for health grey literature in Iran, including two main categories (and some sub-categories): managerial issues (performance related issues, coordination issues, monitoring and supervision issues and attitudinal issues) and issues on data integration (data collecting issues, data recording issues, quality control issues, and issues on data organization, dissemination and use). Conclusion: Designing a national system for health grey literature in Iran needs a powerful authority, removing possible intersectional conflicts, a selection committee, written policies and strict quality control criteria, and protocols for storage, access, retrieval and metadata evaluation.