For isolating multi-dimensional vibration experienced by vehicle-mounted precise facility, a multidimensional vibration isolator based on parallel mechanism with joint clearance is designed and analyzed. The main thrust of the work is establishing kinematic and dynamic equations of the isolator, and exploring vibration isolation capability with joint clearance. Firstly, type synthesis of the parallel mechanism with three translations and one rotation is performed. The kinematic and dynamic equations of the isolator with joint clearance are deduced. Subsequently, vibration isolation performance is simulated with different values of joint clearance under harmonic and stochastic excitations in time and frequency domain respectively. The simulating results demonstrate the proposed isolator with joint clearance inhibit multi-dimensional vibration effectively. The first order resonance peak is sensitive to the increment of joint clearance. Finally, the proposed multi-dimensional vibration isolator is fabricated. The vibration isolation experiment is conducted. Through experimental results, the isolator reduces multi-dimensional vibration effectively in time and frequency domain significantly. The vibration isolation capability degenerates as the counterweight of moving platform increasing.