Grey-scale contrast enhancement in rabbit liver with SonoVue™ at different doses

Gray Scale Contrast Enhancement and Quantification in Different Positions of Rabbit Liver

“…On the basis of a previous study, SonoVue at 0.1 mL/kg BW was the optimal dose for rabbit liver flow perfusion. 13 As shown in our experiment, low-MI gray scale imaging clearly delineated the dynamic enhancement of the liver parenchyma. After the UCA was injected, the liver parenchyma was enhanced and rapidly increased to the PSI.…”

“…[10][11][12] A bubble nondestruction method with a very low mechanical index (MI) and high sensitivity for harmonics is likely to be the most suitable for perfusion and reperfusion studies. [13][14][15] With the use of the real-time low-MI mode, the time-intensity curve could be calculated more accurately because bubbles are not destroyed. 16,17 However, the data for parameters derived from the time-intensity curve may be related to the different position of perfusion quantification, and they have not yet been shown in detail to date.…”

“…Results of an animal model revealed a progressive increase of PSI along with an increase of the SonoVue dose in a certain range. 13 Albrecht et al 17 also found that Doppler signal changes that occur during the microbubble first pass could be quantified by measurement of the intensity of the spectral Doppler signal. This intensity correlates well with the microbubble concentration in vitro and in vivo.…”

Contrast‐enhanced Ultrasonography of the Small Bowel in Healthy Cats

“…8 Several other factors, such as technical scanning variables, contrast medium characteristics, injection technique, and patient-related factors can influence quantitative variables. 2,5,8,[43][44][45][46] Peak intensity values were lower in comparison to those reported by others. 8 The use of different contrast media and different imaging system implies a different number of circulating microbubbles and, as a consequence, a different backscatter response from the tissue that influences the degree of contrast enhancement.…”

“…5,44,46 Because of these reasons, quantitative values obtained from different protocols are not entirely comparable. 2,5,8,[43][44][45][46] Fasting for at least 12 h before contrast-enhanced ultrasonography of the bowel is suggested to minimize the presence of gas and food particles 26 that create strong interference during the activation of the contrast-specific software. Furthermore, fasting is recommended to reduce the peristaltic activity 26 to avoid motion artefact that limits quantitative analysis.…”