GRG Profiles: John M. Carethers

Carethers, John M.

doi:10.1007/s10620-016-4058-9

Cited by 4 publications

(8 citation statements)

References 32 publications

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“…My own pathway to becoming a physician-scientist I was fortunate to have nurturing parents who, despite not having the financial means, pushed higher education on all 12 of their children (19). During my undergraduate education, where I had a strong desire to apply for medical school, I had no real lab experiences.…”

Section: Diversification Leads To Better Sciencementioning

confidence: 99%

“…During my undergraduate education, where I had a strong desire to apply for medical school, I had no real lab experiences. After my first year in medical school, I was fortunate to have research laboratory exposure that piqued my interest in academia and research (and my first research publications), followed by fourth-year electives in a research laboratory (19). During residency, there was minimal time to conduct research, but specific role models steered and solidified my thinking towards an investigative career.…”

Section: Diversification Leads To Better Sciencementioning

confidence: 99%

“…After applying to fellowship programs that held T32 grants, and after evaluating one potential mentor who introduced me to my ultimate research mentor, I began a research focus in colorectal cancer and was mentored in grant and manuscript writing and approaches to answer patient-oriented scientific questions. I spent five years in my research mentor's laboratory to gain a footing in research (19). Along the way, I also learned and was exposed to work-life balance approaches emulating from my the number and total amount of awards, with success rates for RPGs at 20.2% for 2018 (12).…”

Section: Diversification Leads To Better Sciencementioning

confidence: 99%

See 2 more Smart Citations

Diversification in the medical sciences fuels growth of physician-scientists

Carethers¹

2019

Journal of Clinical Investigation

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Section: Diversification Leads To Better Sciencementioning

confidence: 99%

Section: Diversification Leads To Better Sciencementioning

confidence: 99%

Section: Diversification Leads To Better Sciencementioning

confidence: 99%

See 1 more Smart Citation

Diversification in the medical sciences fuels growth of physician-scientists

Carethers¹

2019

Journal of Clinical Investigation

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“…People suffering from IBD are at increased risk of developing CRC 26 . Because of the close link between inflammation and carcinogenesis, it is urgent to clarify the underlying molecular mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Analysis of metabonomic profiling alterations in a mouse model of colitis-associated cancer and 2-deoxy-d-glucose treatment

Yang

Zhang

et al. 2016

RSC Adv.

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Inflammation is well recognized to be associated with tumorigenesis, cancer progression and tumor metabolism of colorectal cancer (CRC). 2-Deoxy-D-glucose (2-DG), a glycolytic inhibitor, has been reported to possess anticancer properties and considered to be a promising treatment for tumor. However, the metabolic alteration in tumorigenesis causes by inflammation and 2-DG prevention remains elusive. In this study, a gas chromatography time-of-flight mass spectrometry (GC-TOF/MS) analysis was applied to investigate the anticancer activity of 2-DG on the alteration of metabolites in a colitis-associated cancer model induced by Azoxymethane (AOM) and dextran sodium sulfate (DSS). We showed that 2-DG obviously decreased the incidence of tumor formation induced by AOM and DSS. 14 metabolites were significantly decreased in AOM/DSS group, while all these metabolites were reversed by 2-DG treatment. Furthermore, the metabolic pathway analysis (MetPA) was introduced to reveal that the involvement of four metabolic networks including linoleic acid metabolism, pentose phosphate pathway, nicotinate and nicotinamide metabolism and inositol phosphate metabolism. The significantly altered metabolites of linoleic acid, nicotinamide, ribose-5-phosphate and myo-inositol were involved in these four pathways. Moreover, the expression of PKM2, which induced by AOM and DSS, was attenuated by 2-DG treatment. Together, this study provides an insight into how 2-DG plays the anticancer effects and may serve as a therapeutic target for colitis-associated cancer.

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“…Rick has touched the lives of at least 63 investigators exclusive of students and residents. His laboratory has trained the likes of John Carethers 4 and Ajay Goel, the authors of this communication, as well as Steve Itzkowitz, Bob Bresalier, and Matthew Yurgelun (mentioned previously, now on the faculty of Harvard Medical School), Chris Arnold, Francesc Balaguer, Dong Chang, Christoph Gasche, Mary Hawn, Sherry Huang, Mike Kochman, Luigi Laghi, Graeme Macdonald, Giancarlo Marra, Luigi Ricciardiello, Yaron Niv, Juichi Sato, Jim Scheiman, and Erica Villa, among others. He has and continues to provide mentorship and advice to many who have not directly worked in his laboratory.…”

Section: Contributions To the Aga Leadership Roles And Mentorshipmentioning

confidence: 99%