Grid laser treatment in macular branch retinal vein occlusion

Parodi, Maurizio Battaglia; Saviano, Sandro; Ravalico, Giuseppe

doi:10.1007/s004170050339

Cited by 77 publications

(43 citation statements)

References 5 publications

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“…[2][3][4][5] It has also been suggested that even in I-BRVO patients with intact foveal avascular zones, improvement with treatment may not be significantly different from that seen in the natural history of I-BRVO patients as a group. [6][7][8] Clearly, the patients in this study benefited from treatment, most remarkably Cases 1 and 3 where ischaemia extended into the foveal avascular zone. When comparing these results with previous studies, it is noteworthy that in each case, the grid laser treatment applied was more intense than Branch Vein Occlusion Study Group 2 recommendations.…”

Section: Commentmentioning

confidence: 71%

Criteria for improving visual acuity in ischaemic branch retinal vein occlusion using argon laser

Zaidi

Gair

Gregory-Evans

2004

Eye

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Section: Commentmentioning

confidence: 71%

Criteria for improving visual acuity in ischaemic branch retinal vein occlusion using argon laser

Zaidi

Gair

Gregory-Evans

2004

Eye

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“…All of the patients had significant macular edema, which was defined as retinal thickening at least one optic disc area in size that involved the fovea [11]. The following exclusion criteria were employed for this study: (1) previous ocular surgery or vitreous injection of anti-VEGF agents and triamcinolone acetonide, (2) previous retinal photocoagulation (including macular photocoagulation), (3) diabetes mellitus with diabetic retinopathy, (4) iris rubeosis, and (5) a history of ocular inflammation and vitreoretinal disease.…”

Section: Methodsmentioning

confidence: 99%

Inflammatory Factors in Major and Macular Branch Retinal Vein Occlusion

et al. 2012

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Concentrations of inflammatory factors were measured in 40 patients with macular edema due to major branch retinal vein occlusion (BRVO) or macular BRVO who were treated by pars plana vitrectomy. Vitreous fluid levels of vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and pigment epithelium-derived factor (PEDF) were determined. Visual acuity and central macular thickness were significantly improved at 6 months in both groups. Vitreous fluid levels of VEGF and sICAM-1 were higher in the major BRVO group than the macular BRVO group, while the PEDF level was lower in the major group than the macular group. The mean visual acuity and central macular thickness at 6 months were not significantly different between the macular and major groups. In conclusion, patients with major BRVO had higher vitreous levels of inflammatory factors and lower vitreous levels of anti-inflammatory PEDF. Accordingly, regulating inflammatory factors might be more important in major BRVO than macular BRVO.

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“…Significant macular oedema was defined as retinal thickening of one optic disc area or greater in size, involving the fovea. 17 The exclusion criteria for this study were as follows: (1) previous ocular surgery, (2) patients with diabetes mellitus and diabetic retinopathy, (3) patients with iris rubeosis, (4) a history of ocular inflammation and vitreoretinal disease, and (5) patients who had the complications, such as intraoperative capsule breaks and dialysis during cataract surgery and long duration (over 20 min) of cataract surgery to avoid the possibility of influence of the vitreous levels of VEGF and IL-6. Combined vitrectomy and cataract operation was performed at the Hiroshima University School of Medicine and Hiroshima Prefectural Hospital.…”

Section: Methodsmentioning

confidence: 99%

Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion

Noma

Funatsu

Yamasaki

et al. 2006

Eye

253

179

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Aim To investigate whether the aqueous levels of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) are correlated to the vitreous levels of these substances and to the severity of macular oedema in branch retinal vein occlusion (BRVO). Methods Aqueous and vitreous samples were obtained during cataract and vitreous surgery from 24 patients (24 eyes) with macular oedema in BRVO. The VEGF and IL-6 levels in aqueous humour, vitreous fluid, and plasma were determined by enzyme-linked immunosorbent assay. The degree of retinal ischaemia was evaluated in terms of the area of capillary nonperfusion using the Scion Image. The severity of macular oedema was evaluated using the OCT. Results The aqueous level of VEGF was significantly correlated with the vitreous level of VEGF (Po0.0001). Vitreous levels of VEGF and IL-6 were significantly correlated with the nonperfusion area of BRVO (Po0.0001, P ¼ 0.0061, respectively), as were the aqueous levels of VEGF and IL-6 (Po0.0001, P ¼ 0.0267, respectively). Furthermore, the vitreous levels of VEGF and IL-6 and the aqueous level of VEGF were significantly correlated with the severity of macular oedema of BRVO (P ¼ 0.0001, P ¼ 0.0331, P ¼ 0.0272, respectively). Conclusion Our results suggest that the aqueous level of VEGF may reflect its vitreous level. Measurement of the aqueous level of VEGF may be clinically useful to indicate the severity of macular oedema with BRVO.

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Grid laser treatment in macular branch retinal vein occlusion

Abstract: We hypothesize that the abrupt ischemic damage subsequent to MBRVO is the main factor causing the central function impairment. Grid laser treatment is not able to reduce the macular edema more than the natural evolution, and does not improve visual acuity.

Cited by 77 publications

References 5 publications

Criteria for improving visual acuity in ischaemic branch retinal vein occlusion using argon laser

Criteria for improving visual acuity in ischaemic branch retinal vein occlusion using argon laser

Inflammatory Factors in Major and Macular Branch Retinal Vein Occlusion

Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion

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