Background and Aims
Electroanatomical mapping may be critical to identify atrial fibrillation (AF) subjects that require substrate modification beyond pulmonary vein isolation (PVI). The objective was to determine correlations between pre-ablation mapping characteristics and 12-month outcomes after a single PVI-only catheter ablation of AF.
Methods
This study enrolled paroxysmal AF (PAF), early persistent AF (PsAF; 7 days-3 months) and non-early PsAF (>3 months-12 months) subjects undergoing de novo PVI-only radiofrequency catheter ablation. Sinus rhythm and AF voltage maps were created with the Advisor HD Grid™ Mapping Catheter, Sensor Enabled™ for each subject and presence of low voltage area (low voltage cutoffs: 0.1 mV-1.5 mV) was investigated. Follow-up visits were at 3-, 6- and 12-months, with a 24-hour Holter monitor at 12-months. A Cox proportional hazards model identified associations between mapping data and 12-month recurrence after a single PVI procedure.
Results
The study enrolled 300 subjects (113 PAF, 86 early PsAF, 101 non-early PsAF) at 18 centers. At 12-months, 75.5% of subjects were free from AF/atrial flutter (AFL)/atrial tachycardia (AT) recurrence. Univariate analysis found arrhythmia recurrence did not correlate with AF diagnosis, but low voltage area was significantly correlated. Low voltage area (<0.5 mV) greater than 28% of the left atrium in sinus rhythm (HR:4.82, 95% CI:2.08-11.18, p = 0.0003) and greater than 72% in AF (HR:5.66, 95% CI:2.34-13.69, p = 0.0001) was associated with higher risk of AF/AFL/AT recurrence at 12-months.
Conclusion
Larger extension of low voltage area was associated with increased risk of arrhythmia recurrence. These subjects may benefit from substrate modification beyond PVI.