Grifola frondosa may play an anti-obesity role by affecting intestinal microbiota to increase the production of short-chain fatty acids

Hu, Ruxiao

doi:10.3389/fendo.2022.1105073

Cited by 7 publications

(5 citation statements)

References 57 publications

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“…The flora that differed between the CC and YC group were unclassified_Muribaculaceaeand unclassified_Oscillospiraceae. Hu et al found that Grifola frondosa powder suspension (GFPS, powder of a medicinal fungus with antiobesity properties) can reduce body weight and increase the abundance of unclassified_Muribaculaceae in the intestinal flora of mice (61), which is exactly consistent with our results. unclassified_ Muribaculaceae is a bacterium that produces short-chain fatty acids, which are important in regulating glucose and lipid metabolism.…”

Section: Discussionsupporting

confidence: 92%

Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota

Guan,

Zheng,

Bai

et al. 2024

Front. Vet. Sci.

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IntroductionYupingfeng polysaccharide (YPF-P) is the main substance of alcohol deposition in Yupingfeng powder, which has many biological functions such as enhancing immunity, repairing intestinal barrier and enhancing antioxidant ability. This study employed in vitro growth-promoting drug feed additives and animal experiments to comprehensively evaluate the use of YPF-P in broiler production.MethodsA total of 1,296 151 days-old Qingyuan Partridge chickens were randomly divided into four groups with six replicates and 54 hens per replicate: the control group was fed basal diet, and the experimental groups were fed diets supplemented with 4 g/kg, 8 g/kg, and 12 g/kg YPF-P for 14 days. Broilers were weighed before and at the end of the experiment to calculate total weight gain (GW), average daily gain (ADG), and feed compensation. At the end of the experiment, six chickens from each group were randomly selected for subwing vein blood sampling, which was used to measure serum biochemical indicators GHRH, GH, and IGF-1 by ELISA method. Randomly select chickens from control group and 8 g/kg group for slaughter, and cecal contents were collected for 16S high-throughput sequencing.ResultsDietary supplementation of 8 g/kg YPF-P can significantly increase the final body weight, total weight gain, average daily gain and decrease the feed to gain ratio of chickens. During 151–165 days, serum IGF-1 concentrations increased significantly (p < 0.05). There were no significant changes in serum GH concentration (p > 0.05). In terms of gut microbiota, there was no significant difference between control group and test group in Shannon index and Simpson index. Compared with the control group,the addition of 8 g/kgYPF-P significantly increased the abundance of Firmicutes and significantly decreased the abundance of Bacteroides at the phylum level.At the genus level, the relative abundance of unclassified_Oscillospiraceae was significantly increased and the unclassified_Muribaculaceae, uncultured_Bacteroidales_bacterium, Lactobacillus, Alloprevotella, Ligilactobacillus, Prevotellaceae_UCG_001, and unclassified_Atopobiaceae was significantly decreased.ConclusionThe above results showed that adding 8 mg/kg of YPF-P could increase the average daily gain of Qingyuan Partridge chickens, reduce the ratio of feed to meat, and affect the distribution proportion of intestinal microflora in chickens to some extent.

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Section: Discussionsupporting

confidence: 92%

Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota

Guan,

Zheng,

Bai

et al. 2024

Front. Vet. Sci.

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“…HQGCD could reduce the abundance of Proteobacteria and Campylobacterota in the cecum of mice. At the genus level, unclassified_Muribaculaceae shows shows a negative correlation with inflammatory factors TNF-α and IL-1β ( Hu, 2022 ). Unclassified_Lachnospiraceae is enriched in the intestine and positively impacts host health.…”

Section: Discussionmentioning

confidence: 99%

Effects of Huangqi Gancao Decoction on intestinal immunity and microbiota in immunocompromised mice models

Zhou,

Yan,

Zhou

et al. 2024

Front. Pharmacol.

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Background:The classical medicinal formula Huangqi Gancao Decoction (HQGCD), originating from the medical book" Yi Lin Gai Cuo". Up to now, the studies focusing on the immunoenhancement effects of HQGCD are few, and the actionpathway is not yet clear.Method:In this study, SPF male KM mice were utilized as a model for immunosuppression. Comprehensive observations were made regarding the general behavior and condition of the mice, in addition to monitoring fluctuations in body weight and food intake. The blood routine index was measured, and morphological changes in the ileum and colon tissues were examined. The level of secretory immunoglobulin A (sIgA), superoxide dismutase (SOD), and malondialdehyde (MDA) in ileum and colon tissues were quantified. Additionally, the bone marrow total DNA index was assessed. Flow cytometry analyzed the proportions of CD3⁺, CD4⁺, CD8⁺, and CD4+CD8+ double-positive (DP) T lymphocytes in small intestinal intraepithelial lymphocytes (IELs). Lastly, the composition and diversity of the cecal microbiota were evaluated using 16S rDNA sequencing technology.Results:After HQGCD intervention, there were no significant changes in the mice’s feed intake and body weight. However, the tissue structures of the ileum and colon showed recovery. In the blood routine index, there was an increase in the total white blood cell count, lymphocyte count, red blood cell count, hematocrit, and hemoglobin content. Additionally, the bone marrow total DNA index was elevated. Level of SOD and sIgA in ileum and colon tissues increased, while the level of MDA decreased. The proportions of CD3⁺ and CD4⁺ T lymphocytes within IELs increased, along with an increase in DP T lymphocytes in IELs (DP IELs), whereas the proportion of CD8⁺ T lymphocytes decreased. The cecal microbiota underwent changes, with an increase in the variety and number of beneficial microbiota.Conclusion:HQGCD could restore the intestinal immune function of immunocompromised mice, and had a certain positive effect on cecal microbiota.

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“…However, Clostridium sensu stricto 1 , Proteus , and Gemella have been proven to have a role in accelerating the occurrence of IBD ( Lopez-Dupla et al., 1996 ; FitzGerald et al., 2006 ; Garrett et al., 2010 ; Wen et al., 2021 ). Inclusively, Marvinbryantia , Rikenellaceae RC9 gut group , Akkermansia , Alloprevotella , Odoribacter , and Clostridia UCG 014 were all potential beneficial bacteria that could promote the synthesis of short-chain fatty acids (SCFAs) with the function of inhibiting the expression of inflammatory factors ( Gao et al., 2022 ; Hu, 2022 ; Leibovitzh et al., 2022 ; Cai et al., 2023 ; Gao et al., 2023 ; Han et al., 2023 ). Therefore, the dramatic changes in Escherichia-Shigella and Muribaculaceae relative abundance might be one of the main reasons for deterioration and death from days 36 to 45.…”

Section: Discussionmentioning

confidence: 99%

Bacillus amyloliquefaciens alleviates the pathological injuries in mice infected with Schistosoma japonicum by modulating intestinal microbiome

Chen

Sun

Wang

et al. 2023

Front. Cell. Infect. Microbiol.

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Schistosoma japonicum causes serious pathological organ damage and alteration of the intestinal microbiome in the mammalian host, threatening the health of millions of people in China. Bacillus amyloliquefaciens has been reported to be able to alleviate the damage to the gut and liver and maintain the homeostasis of the intestinal microenvironment. However, it was unclear whether B. amyloliquefaciens could alleviate the hepatic and intestinal symptoms caused by S. japonicum. In this study, the intragastric administration of B. amyloliquefaciens was performed to treat S. japonicum-infected mice during the acute phase. Histopathological analysis and 16S rRNA gene sequencing were used to evaluate the pathological damage and changes in the intestinal microbiome. The results of the study showed that B. amyloliquefaciens treatment significantly reduced the degree of granuloma and fibrosis in infected mice. Additionally, recovery of diversity in the intestinal microbiome, decrease in the relative abundance of potential pathogenic bacteria such as Escherichia–Shigella, and reshaping of the interactive network between genera in the intestine were also observed after treatment with B. amyloliquefaciens. Our findings indicated that treatment with B. amyloliquefaciens effectively alleviated the pathological injuries of the liver and intestine in mice infected with S. japonicum by modulating the intestinal microbiome, implying that this probiotic can function as an effective therapeutic agent against schistosomiasis. We hope our study will provide auxiliary strategies and methods for the early prevention of schistosomiasis japonica.

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Grifola frondosa may play an anti-obesity role by affecting intestinal microbiota to increase the production of short-chain fatty acids

Cited by 7 publications

References 57 publications

Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota

Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota

Effects of Huangqi Gancao Decoction on intestinal immunity and microbiota in immunocompromised mice models

Bacillus amyloliquefaciens alleviates the pathological injuries in mice infected with Schistosoma japonicum by modulating intestinal microbiome

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