Mineral particle size is an important parameter in the mineral beneficiation process. In industrial processes, the grinding process produces pulp with qualified particle size for subsequent flotation processes. In this paper, a hierarchical intelligent control method for mineral particle size based on machine learning is proposed. In the machine learning layer, artificial intelligence technologies such as long and short memory neural networks (LSTM) and convolution neural networks (CNN) are used to solve the multi-source ore blending prediction and intelligent classification of dry and rainy season conditions, and then the ore-feeding intelligent expert control system and grinding process intelligent expert system are used to coordinate the production of semi-autogenous mill and Ball mill and Hydrocyclone (SAB) process and intelligently adjust the control parameters of DCS layer. This paper presents the practical application of the method in the SAB production process of an international mine to realize automation and intelligence. The process throughput is increased by 6.05%, the power consumption is reduced by 7.25%, and the annual economic benefit has been significantly improved.