Grinding-induced functionalization of carbon-encapsulated iron nanoparticles

Kasprzak, Artur; Bystrzejewski, M.; Koszytkowska‐Stawińska, Mariola; Popławska, Magdalena

doi:10.1039/c7gc00282c

Cited by 20 publications

(14 citation statements)

References 27 publications

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“…The first weight loss up to 110 °C is related to the presence of moisture in the studied sample. The next weight loss, which starts at 120 °C and is completed at 500 °C, is associated with the presence of the organic moieties attached to CEINs ,,,. Please note that the latter weight loss is not observed for the pristine CEINs.…”

Section: Resultsmentioning

confidence: 96%

“…The next weight loss, which starts at 120°C and is completed at 500°C, is associated with the presence of the organic moieties attached to CEINs. [23,24,33,61] Please note that the latter weight loss is not observed for the pristine CEINs. The weight loss for CEINs ∼ PEI ∼ FA (material 5 and 6) is higher than for the reactant (CEINs ∼ PEI, material 3 or 4).…”

Section: Conjugation Of Folic Acid To Ceins ∼ Peimentioning

confidence: 97%

“…Carbon‐encapsulated iron nanoparticles (CEINs) have the core‐shell structure. The metallic iron core is encapsulated in the tight carbon coating which is made of few‐layer graphene . The carbon coating in CEINs is to protect the metallic core against oxidation and agglomeration or aggregation.…”

Section: Introductionmentioning

confidence: 99%

“…The metallic iron core is encapsulated in the tight carbon coating which is made of few-layer graphene . [21][22][23][24] The carbon coating in CEINs is to protect the metallic core against oxidation and agglomeration or aggregation. Carbon-encapsulated iron nanoparticles have better magnetic performance in comparison to iron oxides.…”

Section: Introductionmentioning

confidence: 99%

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Folic Acid‐Navigated and β‐Cyclodextrin‐Decorated Carbon‐Encapsulated Iron Nanoparticles as the Nanotheranostic Platform for Controlled Release of 5‐Fluorouracil

et al. 2018

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The theranostic probe based on carbon‐encapsulated iron nanoparticles (CEINs) is presented. First, the conjugates of CEINs and polyethylenimine (PEI) were obtained to modify the surface of CEINs with amino groups. It was archived either by means of direct radical addition of PEI to CEINs (CEINs‐NH‐PEI material) or the amidation‐type reaction between CEINs∼COOH and the polymer (CEINs∼CONH‐PEI material obtained). β‐Cyclodextrin (βCD) was selected as the drug delivery vector. βCD was covalently anchored to the PEI‐functionalized CEINs via the 1,1’‐carbonyldiimidazole‐mediated reaction. The synthesis included the conjugation of folic acid (FA; targeting ligand) to CEINs via the carbodiimide‐mediated amidation‐type process. The innovative method for excluding a side process of the FA@βCD complex formation during the FA conjugation to PEI, was developed. 5‐Fluorouracil (5‐FU) was chosen as the representative drug molecule. 5‐FU was anchored to the CEINs∼PEI∼βCD∼FA nanoplatforms employing the host‐guest chemistry of βCD. The success of the reactions was confirmed by infrared spectroscopy and thermogravimetry. The content of anchored organic compounds depends on the type of linkage between PEI and CEINs. Additionally, 5‐FU release profile was examined at various pH. The highest release of 5‐FU was observed at pH 9.0, whilst the lowest at pH 4.7. This work sheds a new light on application of carbon‐encapsulated iron nanoparticles in nanomedicine as the novel drug delivery theranostic systems.

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Section: Resultsmentioning

confidence: 96%

Section: Conjugation Of Folic Acid To Ceins ∼ Peimentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Folic Acid‐Navigated and β‐Cyclodextrin‐Decorated Carbon‐Encapsulated Iron Nanoparticles as the Nanotheranostic Platform for Controlled Release of 5‐Fluorouracil

et al. 2018

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“…This temperature range is typical of the decomposition of covalently attached moieties to CEINs. 20,26,32 The functionalization yields ranging from 12 wt% to 21 wt% are summarized in Table 1. The details of the calculation are presented in the ESI (section S6 †).…”

mentioning

confidence: 99%