Grip force control and hand dexterity are impaired in individuals with diabetic peripheral neuropathy

Lima, Kauê Carvalho de Almeida; Borges, Leandro; Hatanaka, Elaine; Rolim, Luiz Clemente; Freitas, Paulo Barbosa de

doi:10.1016/j.neulet.2017.08.071

Cited by 26 publications

(14 citation statements)

References 35 publications

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“…While a previous meta-analysis showed hand grip strength, pinch strengths, and dexterity tended to be worse in patients with type 2 diabetes than in healthy people, differences were not statistically significant [20]. Hand grip strength were found not to differ between type 2 diabetes patients, with and without DPN, in a Brazilian population [21]. In contrast to this previous report, our study showed an association between weakened hand grip strength and DPN in a Japanese population.…”

Section: Discussioncontrasting

confidence: 99%

Inverse Correlation Between Grip Strength and Serum Phosphorus: A Retrospective Observational Study in Japanese Elderly with Poorly Controlled Type 2 Diabetes

et al. 2020

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The aim of this study was to investigate factors associated with sarcopenia among elderly patients with poorly controlled diabetes mellitus (DM). We retrospectively analyzed 41 patients with type 2 DM, aged ≥65 years who required diabetes education hospitalization. Patients were classified into two groups according to the presence or absence of a weakened hand grip, and clinical characteristics were compared. Patients with a weakened hand grip (n = 21) scored worse on a mini-mental state examination (24.3 vs. 26.5, p = 0.04), showed a higher prevalence of diabetic peripheral neuropathy (76% vs. 40%, p = 0.03), and had a higher serum phosphorus concentration (3.8 vs. 3.3 mg/dL, p < 0.01) compared to those without a weakened hand grip (n = 20). The serum phosphorus concentration was inversely correlated to hand grip strength (r = −0.501, p < 0.001) among the total of 41 patients. This inverse association was also confirmed after adjusting the effects of estimated glomerular filtration rate, age, and glycated hemoglobin. Thus, cognitive impairment, diabetic peripheral neuropathy, and high serum phosphorus concentrations are associated with hand grip weakness in elderly patients with type 2 DM.

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Section: Discussioncontrasting

confidence: 99%

Inverse Correlation Between Grip Strength and Serum Phosphorus: A Retrospective Observational Study in Japanese Elderly with Poorly Controlled Type 2 Diabetes

et al. 2020

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“…Diabetic neuropathy (DN) is one of the most common diabetic complications and is characterized by complex changes in functional and sensorimotor parameters (2). The pathophysiology of DN involves a complex cascade of specific interrelated mechanisms (3,4). Oxidative stress is an important contributor to the development of DN; this is due to the dramatic increase in the level of free radicals generated in patients with diabetes (5,6).…”

Section: Introductionmentioning

confidence: 99%

The combined effect of mesenchymal stem cells and resveratrol on type 1 diabetic neuropathy

et al. 2019

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Diabetic neuropathy (DN) is one of the most common diabetic complications that results in an increase in patient discomfort and pain. The present study demonstrated that mesenchymal stem cells (MSCs) or resveratrol (RSV) may improve diabetic hyperglycemia and neuropathy. The aim of the present study was to investigate the combined effect of MSCs and RSV on DN. A total of 100 non-obese diabetic mice were divided into the following six groups: Normal control, MSCs, RSV, MSCs + RSV, insulin and diabetic control groups. Following homologous therapy, the levels of blood glucose and C-peptide, islets, nuclear factor (NF)-κB, nerve growth factor (NGF) and myelin basic protein (MBP), and the sciatic nerve structure in each group were examined and evaluated. Following the administration of therapy, the levels of blood glucose and C-peptide in mice in the MSCs + RSV group were significantly improved when compared with the other diabetic groups, and the dosage of insulin therapy required was the lowest among the six experimental groups (P<0.05). The levels of NGF, MBP and NF-κB in the MSCs + RSV group were significantly improved compared with the MSCs and RSV groups (P<0.05). Furthermore, the diameter of the axon, number of myelinated nerve fibers and the depth of the myelin sheath in the MSCs + RSV group were greatest among the five examined groups (excluding the control). The combination of RSV and MSCs could relieve hyperglycemia and improve DN. This indicated that the combination of RSV and MSCs may be a novel therapeutic method for the treatment of DN.

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“…Since 1988, the test is used as an upper limb outcome measurement in multiple sclerosis, a disease with an involvement of the corticospinal tract [6]. In the last years, the NHPT could be assessed as a reliable test for dexterity in other diseases of the central nervous system such as stroke [7], traumatic brain injury [8], and cerebral palsy [9] but also for diseases with an involvement of the lower motor neurons as peripheral neuropathies [10, 11]. Transcranial magnetic stimulation (TMS) with resting-motor threshold (RMT) is a tool to show the involvement of the UMNs.…”

Section: Introductionmentioning

confidence: 99%

Nine Hole Peg Test and Transcranial Magnetic Stimulation: Useful to Evaluate Dexterity of the Hand and Disease Progression in Amyotrophic Lateral Sclerosis

Czell

Neuwirth

Weber

et al. 2019

Neurology Research International

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Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with involvement of the upper and lower motor neurons. Since the loss of fine motor skills is one of the earliest signs of ALS, the hypothesis was tested if the nine hole PEG test (NHPT) and transcranial magnet stimulation (TMS) with resting-motor threshold (RMT) could be useful in monitoring disease progression. Methods We examined 28 ALS patients and 27 age-matched healthy controls. ALS patients and healthy controls underwent the nine hole peg test (NHPT) and TMS with RMT. Measurements in patients were repeated after three and six months. Results At baseline, the median NHPT durations were 1,4-fold longer (p < 0.001), and TMS scores showed a significant 0.8-fold smaller score in ALS patients compared with healthy controls (p < 0.001). The comparison of three and six months versus baseline revealed significant differences for NHPT durations and ALSFRS-R in patients, whereas TMS scores did not significantly differ in the patients. Conclusion NHPT seems to be a good tool to evaluate dexterity of the hand and the progression of the disease in ALS patients. TMS RMT to the hand muscles seems to be poorly qualified to evaluate the dexterity of the hand function and the course of the disease.

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Grip force control and hand dexterity are impaired in individuals with diabetic peripheral neuropathy

Cited by 26 publications

References 35 publications

Inverse Correlation Between Grip Strength and Serum Phosphorus: A Retrospective Observational Study in Japanese Elderly with Poorly Controlled Type 2 Diabetes

Inverse Correlation Between Grip Strength and Serum Phosphorus: A Retrospective Observational Study in Japanese Elderly with Poorly Controlled Type 2 Diabetes

The combined effect of mesenchymal stem cells and resveratrol on type 1 diabetic neuropathy

Nine Hole Peg Test and Transcranial Magnetic Stimulation: Useful to Evaluate Dexterity of the Hand and Disease Progression in Amyotrophic Lateral Sclerosis

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