Grip strength as a predictor of postoperative delirium in patients with colorectal cancers

Arita, Asami; Takahashi, Hidekazu; Ogino, Takayuki; Miyoshi, Norikatsu; Uemura, Mamoru; Akasaka, Hiroshi; Sugimoto, Ken; Rakugi, Hiromi; Doki, Yuichiro; Eguchi, Hidetoshi

doi:10.1002/ags3.12519

Cited by 10 publications

(21 citation statements)

References 33 publications

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“…21 Arita et al reported that the incidence of postoperative delirium was 13.3% in patients ≥70 years old who underwent colorectal cancer surgery. 25 This difference in the incidence of postoperative delirium between the present study and previous reports may be due to our setting the target age higher than in other studies, as we targeted patients ≥75 years old in our study. An older age is reported to be an extremely important risk factor for the development of postoperative delirium in predisposed patients.…”

Section: Ta B L E 3 a Comparison Of Preoperative Factors Between Pati...contrasting

confidence: 63%

“…To assess the cognitive function of patients, the MMSE and Hasegawa Dementia Scale‐Revised (HDS‐R) are widely used. An MMSE score <23 is reported as an independent preoperative predictive factor for postoperative delirium in older patients who undergo colorectal surgery (OR 3.50, 95% CI 1.36–9.02, p = 0.009), 25 and an HDS‐R score <20 is reported to be an independent preoperative predictive factor for postoperative delirium in elderly patients who undergo urological surgery (OR 3.50, 95% CI = 1.36–9.02, p = 0.009) 23 . Our study also showed an MMSE ≤24 to be an independent preoperative predictive factor for postoperative delirium, which is consistent with previous reports (Table 5).…”

Section: Discussionmentioning

confidence: 99%

“…Chu et al reported that the incidence of postoperative delirium was 9.6% in patients ≥60 years old who underwent orthopaedic surgery 21 . Arita et al reported that the incidence of postoperative delirium was 13.3% in patients ≥70 years old who underwent colorectal cancer surgery 25 . This difference in the incidence of postoperative delirium between the present study and previous reports may be due to our setting the target age higher than in other studies, as we targeted patients ≥75 years old in our study.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors for postoperative delirium in elderly patients undergoing gastroenterological surgery: A single‐center retrospective study

Sugi

Enomoto

Ohara

et al. 2023

Annals of Gastroent Surgery

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AimTo investigate the risk factors for postoperative delirium among elderly patients undergoing elective surgery for gastroenterological cancer.MethodsFrom May 2020 to March 2022, patients ≥75 years old with gastroenterological cancer who underwent radical surgery were enrolled. The geriatric assessment, including evaluations of frailty, physical function, nutrition status, and cognitive function, was conducted preoperatively. The confusion assessment method was used to diagnose postoperative delirium. A multivariate logistic regression analysis was used to determine risk factors for postoperative delirium.ResultsA total of 158 patients were eligible for inclusion in this study. Of these 53 patients (34%) developed postoperative delirium. In the univariate analysis, the age, regular use of sleeping drugs and benzodiazepine, Charlson Comorbidity Index score, performance status, Fried's frailty score, Vulnerable Elders Survey‐13 score, grip weakness, Short Physical Performance Battery (SPPB) score, Mini Nutritional Assessment Short‐Form score, and Mini‐Mental State Examination score were statistically associated with the incidence of postoperative delirium. In the multivariate analysis, a SPPB score ≤9, Mini Nutritional Assessment score ≤11, a Mini‐Mental State Examination score ≤24, and regular use of benzodiazepine were found to be independent preoperative risk factors for postoperative delirium.ConclusionCertain findings during the preoperative geriatric assessment, especially low SPPB, Mini Nutritional Assessment Short‐Form and Mini‐Mental State Examination scores, and regular use of benzodiazepine were risk factors for postoperative delirium in elderly patients undergoing gastroenterological surgery.

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Section: Ta B L E 3 a Comparison Of Preoperative Factors Between Pati...contrasting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Risk factors for postoperative delirium in elderly patients undergoing gastroenterological surgery: A single‐center retrospective study

Sugi

Enomoto

Ohara

et al. 2023

Annals of Gastroent Surgery

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“…In addition to RCC, numerous studies have found that PBT has a significant adverse effect on cancer survival in several types of malignant solid tumors, such as gastric, colorectal, and bladder cancer. [ 12 , 31 , 32 ] To explain this phenomenon, several possible mechanisms have been proposed. First, these deleterious effects are thought to be associated with suppressive transfusion-related immunomodulation (TRIM) and proinflammatory effects mediated by apoptotic cells, residual leukocytes and modified biological response including soluble mediators, cytokines, and soluble HLA peptides.…”

Section: Discussionmentioning

confidence: 99%

Impact of perioperative blood transfusion on prognosis after nephrectomy in patients with renal cell carcinoma: A meta-analysis and systematic review

Xu,

Bai,

Pan

et al. 2024

Medicine

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Background: Perioperative blood transfusion (PBT) has been associated with worse prognosis in several malignancies. For renal cell carcinoma (RCC), the effect of PBT is still debated. Objective: To evaluate the impact of PBT on prognosis after nephrectomy in patients with RCC. Methods: This study is A systematic review and meta-analysis of published article data (PRISMA protocol) for literature related to PBT and RCC through extensive search of EMBASE, Medline via PubMed, Web of Science and Cochrane Library, language limited to English, with no time constraint until May 20, 2022. We pooled the results of multivariable cox regression analyses from each study, with subgroup analyses by dose and timing of transfusion. All analyses were done using Stata14. Results: A total of 12 studies involving 27,683 participants were included. Our meta-analysis pooled the results of multivariable cox regression analysis in each study, showing that PBT is associated with higher overall Mortality (OM; hazard ratio [HR] = 1.34, 1.23–1.44), cancer-specific mortality (CSM; HR = 1.35, 1.20–1.51), and disease recurrence (HR = 1.54, 1.18–1.89). when only patients with nonmetastatic RCC were included, PBT was still associated with higher OM (HR = 1.29, 1.11–1.47) and disease recurrence (HR = 1.58, 1.18–1.98), but the association with CSM (HR = 1.26, 0.99–1.52) was not statistically significant. In subgroup analysis by transfusion dose, small (1–2) units of PBT were not associated with CSM (HR = 1.84, 0.95–2.73), but large (≥3) units were associated with higher CSM (HR = 2.98, 1.74–4.22) and disease recurrence (HR = 1.99, 1.31–2.67). Each additional unit of PBT resulted in a higher CSM (HR = 1.07, 1.04–1.10). In subgroup analysis by transfusion timing, intraoperative transfusion was associated with higher CSM and disease recurrence, but postoperative transfusion was not. Conclusions: PBT is associated with higher OM, CSM and disease recurrence. This adverse effect seems to be particularly significant in high-dose intraoperative transfusion. It is necessary to limit the overuse of PBT, especially high-dose intraoperative transfusion, in order to improve the prognosis of patients undergoing nephrectomy for RCC.

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“…In daily clinical practice, it is time- and manpower-consuming to assess the five aforementioned items. Conversely, hand grip strength can be measured simply and quickly, and some previous studies including surgical and non-surgical hospitalized patients showed that low hand grip strength was associated with the development of delirium [ 5 , 6 ]; however, these associations in patients undergoing cardiac surgery have been poorly documented.…”

Section: Introductionmentioning

confidence: 99%

Association between Preoperative Hand Grip Strength and Postoperative Delirium after Cardiovascular Surgery: A Retrospective Study

Kotani

Ida

Inoue

et al. 2023

JCM

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The association of frailty with postoperative delirium has not been fully investigated in patients undergoing cardiovascular surgery. Therefore, this study aimed to investigate whether preoperative hand grip strength is associated with postoperative delirium. This retrospective study included patients aged >65 years who had undergone elective cardiovascular surgery using cardiopulmonary bypass at a Japanese university hospital between April 2020 and February 2022. We defined low hand grip strength as hand grip values of <275 n and <177 n for men and women, respectively. Postoperative delirium was assessed using the confusion assessment method during patients’ intensive care unit stay. The odds ratio of low hand grip strength for postoperative delirium was estimated using multiple logistic analysis, which was adjusted for prominent clinical factors. Ninety-five patients with a median age of 74 years were included in the final analysis, and 31.5% of them had low hand grip strength. Postoperative delirium occurred in 37% of patients, and the odds ratio of low preoperative hand grip strength for postoperative delirium was 4.58 (95% confidence interval: 1.57–13.2). Thirty-seven patients experienced postoperative delirium after cardiovascular surgery using cardiopulmonary bypass, and low preoperative hand grip strength was positively associated with its occurrence.

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Grip strength as a predictor of postoperative delirium in patients with colorectal cancers

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 10 publications

References 33 publications

Risk factors for postoperative delirium in elderly patients undergoing gastroenterological surgery: A single‐center retrospective study

Risk factors for postoperative delirium in elderly patients undergoing gastroenterological surgery: A single‐center retrospective study

Impact of perioperative blood transfusion on prognosis after nephrectomy in patients with renal cell carcinoma: A meta-analysis and systematic review

Association between Preoperative Hand Grip Strength and Postoperative Delirium after Cardiovascular Surgery: A Retrospective Study

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