Grip strength in children with chronic kidney disease

Hogan, Julien; Schneider, Michael; Pai, Rima; Kogon, Amy J.; Brooks, Ellen R.; Kaskel, Frederick J.; Reidy, Kimberly; Saland, Jeffrey M.; Warady, Bradley A.; Furth, Susan L.; Patzer, Rachel E.; Greenbaum, Larry A.

doi:10.1007/s00467-019-04461-x

Cited by 31 publications

(36 citation statements)

References 22 publications

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“…Preserving muscle strength in patients with cystinosis is important since impaired muscle strength is associated with lower quality of life in both pediatric (15) and adult CKD patients (27). Our study demonstrates the high prevalence of neuro-muscular symptoms in patients with cystinosis.…”

Section: Study Populationmentioning

confidence: 64%

“…This is similar to a previous study investigating the relationship between grip strength and GFR in children with CKD that did not nd a signi cant effect of CKD stages 2-5 on grip strength, although it did report a signi cantly higher grip strength in children with CKD stage 1 compared to all other stages. In the study of children with CKD, risk factors for decreased grip strength included longer duration of CKD, pre-pubertal status, delayed puberty, neuropsychiatric comorbidities, need for feeding support, need for alkali therapy, and hemoglobin level (15). We speculate that, similar to non-cystinosis patient with CKD, the effect of CKD stage is less important compared to other factors that affect grip strength in patients with cystinosis.…”

Section: Study Populationmentioning

confidence: 96%

“…metabolic acidosis, in ammation) and treatments (dialysis) in the loss of muscle mass (14). Among children, a recent paper reported a lower grip strength in CKD patients compared to healthy controls independent of growth retardation and BMI status (15).…”

Section: Introductionmentioning

confidence: 99%

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Grip Strength in Adults and Children with Cystinosis

Iyob-Tessema

Wang

Kennedy

et al. 2020

Preprint

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Background: Chronic kidney disease (CKD) is associated with impaired muscle strength. Cystinosis patients have increased risk for impaired muscle strength due to early development of CKD and cystinosis-induced myopathy. This study assesses muscle strength in cystinosis patients and investigates risk factors of decreased muscle strength. Methods: Adult and pediatric patients were recruited from Cystinosis Research Network conferences and a large pediatric nephrology clinic between 2017 and 2019. Patients and caregivers completed questionnaires on demographic characteristics, disease course, daily physical activity, and neuro-muscular symptoms. Grip strength was assessed using a dynameter and calculated z-scores for age and sex were assessed for associations with patient characteristics. Results: We included 76 patients with a mean grip strength z-score of -2.1 (SD 1.1), which was lower than seen in CKD patients without cystinosis. Male sex and delayed cysteamine initiation were independently associated with impaired grip strength. Among adults, a low level of physical activity was associated with lower grip strength z-score, but no association was found in children. A third of the patients reported neuro-muscular symptoms, with swallowing issues associated with lower grip strength. There was no significant correlation between eGFR and grip strength z-score. Conclusion: Cystinosis patients have impaired muscle strength compared to healthy controls and CKD patients. This impairment is greater in male patients and in patients with late initiation of cysteamine therapy, and is associated with lower physical activity. Further studies investigating the effect of different types of physical activities, optimizing cysteamine therapy and other interventions are needed.

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Section: Study Populationmentioning

confidence: 64%

Section: Study Populationmentioning

confidence: 96%

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Grip Strength in Adults and Children with Cystinosis

Iyob-Tessema

Wang

Kennedy

et al. 2020

Preprint

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“…Indeed, grip strength reported in adult patients with CKD stage 3 to 5 by Zhou et al were higher than those found in our adult patients 25 . In children, when comparing patients at the same CKD stage, cystinosis patients have a grip strength that is more than one standard deviation lower compared CKD controls, who had a mean grip strength z-score of -0.72 15 . These results suggest that the direct effect of cystinosis on muscle strength is additive to the effect of CKD.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 98%

“…This is similar to a previous study investigating the relationship between grip strength and GFR in children with CKD that did not find a significant effect of CKD stages 2-5 on grip strength, although it did report a significantly higher grip strength in children with CKD stage 1 compared to all other stages. In the study of children with CKD, risk factors for decreased grip strength included longer duration of CKD, pre-pubertal status, delayed puberty, neuropsychiatric comorbidities, need for feeding support, need for alkali therapy, and hemoglobin level 15 . We speculate that, similar to non-cystinosis patient with CKD, the effect of CKD stage is less important compared to other factors that affect grip strength in patients with cystinosis.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Grip Strength in Adults and Children with Cystinosis

Iyob-Tessema

Wang

Kennedy

et al. 2021

Kidney International Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Handgrip strength and health outcomes in hospitalized children or children with chronic disease: A systematic review

Verbrugghe,

Larue,

Delcourt

et al. 2024

J. pediatr. gastroenterol. nutr.

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Handgrip strength (HGS) is a simple measurement of maximum voluntary muscle strength and is widely used as a single indicator of overall muscle strength. This systematic review summarized the evidence about the relation between HGS and health outcomes in hospitalized children or chronically ill children. The primary outcome was the number of hospital days in a 2‐month period for outpatients and the length of hospital stay for inpatients. After a systematic search in PubMed, Embase, Lilacs, and the Cochrane Library, 9282 unique papers were screened, 24 included. Studies assessed HGS in children with cystic fibrosis, neuromuscular disease, chronic kidney disease, type 1 diabetes mellitus, asthma, cardiac disease, juvenile idiopathic arthritis, intestinal failure, surgical patients, and a mixed hospitalized population. One study reported that children experienced a decline in HGS during hospitalization which was associated with prolonged hospital stay. Another reported no relation with the number of hospital days in 5 years. No studies reported on the association between HGS and infectious complications or antibiotic use. We did find a positive correlation between HGS and quality of life, different nutritional parameters and inflammatory biochemical markers. We concluded that the relation between HGS and hospital stay in children is poorly studied. HGS showed promise as a functional biomarker for children with chronic health conditions when inflammation is involved, but more attention should be paid to the methodological aspects of assessing HGS.

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Grip strength in children with chronic kidney disease

Cited by 31 publications

References 22 publications

Grip Strength in Adults and Children with Cystinosis

Grip Strength in Adults and Children with Cystinosis

Grip Strength in Adults and Children with Cystinosis

Handgrip strength and health outcomes in hospitalized children or children with chronic disease: A systematic review

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