Grippe A/H1N1 2009 chez des patients transplantés : étude comparative versus des patients non transplantés

Abstract

Our results suggest that H1N1(2009) influenza A infection in transplant recipient patients compared to non-transplanted patients: (1) more often leads to hospitalization; (2) is more frequently associated with pneumonia; (3) is responsible for a persistent graft functional impairment in lung transplant recipients; (4) has a low mortality rate similar to admitted non-transplanted patients.

Effect of the adjuvanted (AS03) A/H1N1 2009 pandemic influenza vaccine on the risk of rejection in solid organ transplant recipients in England: a self-controlled case series

“…Influenza A/H1N1 2009 infection caused substantial morbidity and mortality in SOT recipients worldwide. 2 51–55 In the largest study, involving 237 cases of medically attended H1N1 influenza infections from 26 transplant centres in the USA, infections resulted in hospitalisation in 71%, admission to an intensive care unit in 16%, and death in 4% of cases. 54 Allograft dysfunction and clinical rejection were also reported in SOT recipients following pandemic influenza A/H1N1 infection.…”

“… 54 Allograft dysfunction and clinical rejection were also reported in SOT recipients following pandemic influenza A/H1N1 infection. 2 51–53 56 57 Pandemic influenza vaccination is therefore an important preventive measure in this medically vulnerable population at high risk of complications, and is considered clinically safe and well tolerated despite relatively modest efficacy. 2 58 59 In addition to investigating a safety signal, this study addresses the need for a formal pharmacoepidemiological analysis of the risk of SOT rejection in a large population of transplanted patients.…”