Griseofulvin and its uses

Poly(allylamine) Magnetomicelles for Image Guided Drug Delivery

“…Its hydrophobic nature results in a low aqueous solubility in the gastrointestinal (GI) tract resulting in poor oral bioavailability [37,38]. Griseofulvin is currently administered orally in microcrystalline preparations with prescribed doses of 500-1000 mgday -1 [39]. However, a great deal of inter-and intra-subject variation is experienced, perhaps due to erratic and incomplete absorption of the drug from the GI tract [40].…”

Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development

“…Another successful antifungal agent, griseofulvin, first isolated from the mold Penicillium griseofulvum , has seen additional interest lately due to its anti-proliferative effects in certain cancer cell model systems 25 . A recently identified CYP in its biosynthetic pathway has been shown to be essential for formation of the grisan scaffold 26 .…”

From Nutrition to Health: The Role of Natural Products – A Review

“…Other various newer lipid formulations are also used in handling such disease conditions (Hiemenz and Walsh, 1996). Griseofulvin which was first isolated from the fungus Penicillium griseofulvin has been used in the treatment of dermatophyte infections for the past 30 years (Finkelstein et al, 1996). Polyene antifungal antibiotic nystatin, is used for prophylaxis and treatment of candidiasis of the skin and mucous membranes (Waugh, 2008).…”