Griseofulvin and Some Analogues.

Grove, John Frederick

doi:10.1007/978-3-7091-7145-5_4

Cited by 7 publications

(3 citation statements)

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“…BIRCH'S results are inconsistent with the suggestion by VANEK and SOUCEK (1962) that griseofulvin is formed by condensation of two shorter chains made up from three and four acetate-malonate units, since this scheme would require the presence of two units derived from acetate with five from malonate. BIRCH'S results are also inconsistent with the suggestion, reviewed in greater detail elsewhere (GROVE, 1964), that all mould products formally derived from seven acetate-malonate units, for example, griseofulvin and the following compounds in It is relevant to the suggestion of VANEK and SOUCEK that GATENBECK and MOSBACH (1963) have shown that citromycetin can be formed from two chains, whereas the second, unified, concept accounts readily for the co-metabolites palitantin (Fig. 3, XVII) and citromycetin (Fig.…”

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confidence: 50%

“…More condensed accounts, covering the same period, are included in reviews of the chemistry of griseofulvin and related fungal grisans by GROVE (1963GROVE ( , 1964. There have been few fresh developments in the short time that has elapsed since the pUblication of these reviews.…”

Section: Griseofulvin John Frederick Grovementioning

confidence: 98%

“…received some support from the fact that the reactions (XII) -+ (XIV) -+ (XI) and (XI) -+ (I; R = Cl) had already been achieved in vitro by oxidative phenol radical coupling and stereospecific selective catalytic reduction respectively; for review see GROVE (1964).…”

Section: Griseofulvin 129mentioning

confidence: 99%

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Biosynthesis

1967

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All rights, especially that of translation into f oreign 1anguages, reserved. It is also forbidden to reproduce this book, either who1e or in part, by photomechanical means (photostat, microfilm and/or microcard) or by other procedure without written pennission from Springcr-Vcrlag Berlin Heide1bCig GmbH. DedicationFor most areas of scientific pursuit, there is usually that rare investigator who has the imagination to conceive ideas, who has faith in his visions, and who has the ability to critically test his concepts in the laboratory. Almost invariably, this scientist also inspires younger men to enthusiastically enter into his research program. To him should go the accolades and the recognitions of the esteem in which he is held. As only a small part of this esteem, we wish to dedicate these books to Professor SELMAN A. W AKSMAN in appreciation of his leadership and contributions in all facets of antibiotic research. PrefaceThe idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a bibliography on antibiotics and feel confident that we could find everything that was being published on this sUbject. These fields of investigation were moving forward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master.That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and biosynthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known. Yet, such an approach would not entirely serve the purpose we projected, for it would not encompass all of the information available in these fields of antibiotic investigations and blind searches for the original literature would still have to be made. We therefore chose to include any and all antibiotics about which some pertinent information had been published. It was obvious even at the start that such a compilation, integration, and analysis of information could never be complete unless scientific investigations ceased at the moment the last manuscript was submitted-an end that was neither desirable nor possible. An addendum was therefore included at the end of the volume and left open for the addition of new information until the last pages of the regular articles had been printed.The...

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confidence: 50%

Section: Griseofulvin John Frederick Grovementioning

confidence: 98%