Groin angiosarcoma following radiotherapy for vulvar cancer

Sanz, Clara; Moreno, Fernando; Armas, A.; Casado, Antonio; Castillo, Majin

doi:10.1016/j.ygyno.2004.12.061

Cited by 10 publications

(14 citation statements)

References 13 publications

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“…Reasons for radiation treatment are various but include predominantly malignant and less often benign conditions. By far the most frequent clinical setting is the treatment of breast carcinoma, 5,15–44 followed by gynaecological malignancies such as ovarian, endometrial or uterine cervical carcinoma 23,45–52 . Rare reasons for radiation treatment include congenital haemangioma, acne, ringworm, graft irradiation of a renal transplant and peripheral primitive neuroectodermal tumour, melanoma and Hodgkin's disease 23,53–61 .…”

Section: Cutaneous Angiosarcomamentioning

confidence: 99%

Postradiation vascular proliferations: an increasing problem

2005

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The occurrence of cutaneous vascular lesions is a rare but well-documented complication of radiation treatment and may be associated with significant morbidity as well as mortality. The overall incidence is low but appears to be rising due to a change in the prevailing treatment of breast carcinoma with increased use of radiation in the setting of breast-conserving therapy for stage 1 and 2 disease. The spectrum of postradiation vascular lesions is wide and ranges from atypical vascular lesions with reportedly benign clinical behaviour to frank cutaneous angiosarcoma. There is, however, significant clinical as well as histological overlap. It is frequently difficult to classify these postradiation vascular lesions accurately and they create an emerging diagnostic and therapeutic challenge to both pathologists and clinicians. Experience with these vascular lesions is very limited, and this article aims to provide an overview of our current understanding and concept of radiation-associated vascular lesions with focus on their clinical and histological presentation as well as behaviour and treatment.

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Section: Cutaneous Angiosarcomamentioning

confidence: 99%

Postradiation vascular proliferations: an increasing problem

2005

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“…The system we have used 4 categorizes all lesions into 6 categories, which include cutaneous vascular malformations, 7-11 cutaneous lesions characterized by dilation of preexisting vessels (including varices, 12-14 angiokeratomas, 15,16 and acquired lymphatic lesions 5,17,18 ), cutaneous vascular hyperplasia, [19][20][21][22][23] benign tumors of vascular endothelium, [24][25][26] malignant vascular tumors, [27][28][29][30][31][32] and cutaneous neoplasms with a significant vascular component. The system we have used 4 categorizes all lesions into 6 categories, which include cutaneous vascular malformations, 7-11 cutaneous lesions characterized by dilation of preexisting vessels (including varices, 12-14 angiokeratomas, 15,16 and acquired lymphatic lesions 5,17,18 ), cutaneous vascular hyperplasia, [19][20][21][22][23] benign tumors of vascular endothelium, [24][25][26] malignant vascular tumors, [27][28][29][30][31][32] and cutaneous neoplasms with a significant vascular component.…”

Section: Discussionmentioning

confidence: 99%

Vulvar Vascular Tumors

Papalas¹,

Sangüeza²,

Puri

et al. 2013

The American Journal of Dermatopathology

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The subepidermal hormonally sensitive tissue of the vulva is anatomically unique and may give rise to a wide variety of vascular tumors. As a consequence, classifying vulvar vascular lesions has been challenging due both to the wide variety of lesions that may be encountered and the heterogeneity in reporting across several disciplines. The purpose of this study is to present an institutional experience of vulvar vascular lesions. Overall, 85 patients were identified over a 26-year period. Vascular lesions belonging to the following classes included (n, %total) benign vascular tumors (32, 38%), dilatations of preexisting vessels (31, 36%), hyperplasia/reactive (7, 8%), tumors with significant vascular component (11, 13%), malformations (3, 4%), and malignant vascular tumors (1, 1%). Two reaction patterns based on vulvar lymphatic pathology were identified: one is a stromal dominant pattern and the other is a vascular dominant pattern. Vulvar vascular malformations and true vascular malignancies, although rare, may have associated high morbidity. To accurately classify vulvar lymphatic lesions, the pathologist must carefully consider the patient's clinical history taking into account features such as preexisting lymphedema.

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“…Postradiation angiosarcoma has been reported in the right groin 25 years status post radiotherapy for vulvar squamous cell carcinoma [ 68 ]. In order to associate radiotherapy with the sarcoma development, several criteria must be present: (1) site of sarcoma must be within fi eld of radiotherapy, (2) there must be at least 3-5 years interval, and (3) the induced sarcoma has a different histology than the primary cancer [ 68 ].…”

Section: Clinical Presentationmentioning

confidence: 99%

“…In order to associate radiotherapy with the sarcoma development, several criteria must be present: (1) site of sarcoma must be within fi eld of radiotherapy, (2) there must be at least 3-5 years interval, and (3) the induced sarcoma has a different histology than the primary cancer [ 68 ].…”

Section: Clinical Presentationmentioning

confidence: 99%