Grooved Pegboard Test

Merker, Brad; Podell, Kenneth; Wingate, Melissa

doi:10.1007/978-3-319-57111-9_187

Cited by 9 publications

(14 citation statements)

References 17 publications

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“…If the neuropsychological assessment occurred after treadmill testing, the participant was allowed at least 1 hour of recovery before beginning neuropsychological testing. The neurocognitive domains assessed included: intelligence (Wechsler Abbreviated Scale of Intelligence [WASI‐II]), academic skills (Woodcock‐Johnson III Test of Achievement), attention (Connor's Continuous Performance Test II, Trail Making Test [TMT] part A), memory (California Verbal Learning Test II, Visual Selective Reminding, WASI‐III [digit span forward]), processing speed (Grooved Pegboard Test, WAIS‐III [symbol search and digit symbol coding]), and executive function (TMT part B, Controlled Oral Word Association Test, WAIS‐III [digit span backward]). In addition, survivors completed a self‐rating questionnaire (Behavior Rating Inventory of Executive Function [adult version]), to evaluate perceived neurobehavioral function.…”

Section: Methodsmentioning

confidence: 99%

Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort

Phillips

Howell

Lanctot

et al. 2019

Cancer

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BACKGROUND: Survivors of childhood acute lymphoblastic leukemia (ALL) are at increased risk for both treatment-related exercise intolerance and neurocognitive deficits. This analysis aimed to identify the association between exercise intolerance and neurocognitive impairments in ALL survivors. METHODS: Cardiopulmonary exercise testing, results from a 2-hour standardized neuropsychological assessment, and self-report questionnaires were obtained for 341 adult survivors of childhood ALL and 288 controls. Multivariable modeling was used to test associations between oxygen uptake at 85% estimated heart rate (rpkVO 2 ) and neuropsychological test and self-reported questionnaire domains, adjusted for sex, age at diagnosis, cranial radiation, anthracycline, and methotrexate exposure and tobacco smoking status. RESULTS: Compared with controls, survivors had worse rpkVO 2 and performance on verbal intelligence, focused attention, verbal fluency, working memory, dominant/nondominant motor speed, visual-motor speed, memory span, and reading and math measures (all P < .001). In adjusted models, exercise intolerance was associated with decreases in performance of verbal ability, focused attention, verbal fluency, working memory, dominant motor speed, nondominant motor speed, visual-motor speed, memory span, reading academics, and math academics in survivors. CONCLUSION: This study demonstrates an association between exercise intolerance and neurocognitive outcomes. Research is needed to determine whether interventions that improve exercise tolerance impact neurocognitive function in ALL survivors. Cancer 2020;126:640-648.

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Section: Methodsmentioning

confidence: 99%

Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort

Phillips

Howell

Lanctot

et al. 2019

Cancer

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“…For impact on neurocognition including safety and efficacy, TAND domains were measured by well‐validated, standardized, assessment tools that used direct testing and parent/caregiver report rating scales. Global intellectual ability was assessed using the Wechsler Abbreviated Scale of Intelligence (WASI); language using the Expressive Vocabulary Test 2 (EVT2) and Peabody Picture Vocabulary Test 4 (PPVT4); learning and memory using Cambridge Neuropsychological Test Automated Battery (CANTAB) and Wide Range Assessment of Memory and Learning 2 (WRAML2); attention using CANTAB and WRAML2; executive function using CANTAB; and processing speed using CANTAB and grooved pegboard . Parent rating scales included the Vineland Adaptive Behavioral Scales‐II (VABS2); Behavior Rating Inventory of Executive Function (BRIEF), Behavior Assessment System for Children 2 (BASC2), Strengths and Difficulties Questionnaire (SDQ), and Social Responsiveness Scale (SRS) .…”

Section: Methodsmentioning

confidence: 99%

Everolimus for treatment of tuberous sclerosis complex‐associated neuropsychiatric disorders

Krueger

Sadhwani

Byars

et al. 2017

Ann Clin Transl Neurol

110

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ObjectiveTo evaluate if short‐term treatment with everolimus was safe and could improve neurocognition and behavior in children with TSC.MethodsThis was a prospective, double‐blind randomized, placebo‐controlled two‐center phase II study. Participants diagnosed with TSC and age 6–21 years were treated with 4.5 mg/m2 per day of oral everolimus (n = 32) or matching placebo (n = 15) taken once daily for 6 months. For efficacy, a comprehensive neurocognitive and behavioral evaluation battery was performed at baseline, 3 months, and 6 months. For safety, adverse events recorded continuously via patient diary were categorized and graded per NCI Common Toxicity Criteria for Adverse Events, version 3.0 (CTCAE 3.0). Analyses were performed on the intention‐to‐treat population (n = 47).ResultsNearly all assessment measures failed to demonstrate significant differences between the two groups at the end of 6 months. Only one measure each of executive function (Cambridge Neuropsychological Test Automated Battery Stockings of Cambridge) favoring placebo (P = 0.025) and social cognition (Social Responsiveness Scale Social Cognition Subscale) favoring everolimus (P = 0.011) was observed. A total of 473 adverse events (AE) were reported. The average number of total AE per subject was similar for both placebo and everolimus. Most were mild or moderate in severity and serious AE were rare.InterpretationWhile safe, oral everolimus administered once daily for 6 months did not significantly improve neurocognitive functioning or behavior in children with TSC.

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“…Manual dexterity was subsequently assessed via the grooved pegboard test, indirect and direct zigzag tracking tests, and the 3Dconnexion proficiency test . Validated dexterity tests were selected based on their perceived relevance to basic laparoscopic surgery skills.…”

Section: Manual Dexterity Testsmentioning

confidence: 99%

Investigating the impact of innate dexterity skills and visuospatial aptitude on the performance of baseline laparoscopic skills in veterinary students

et al. 2017

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Grooved Pegboard Test

Cited by 9 publications

References 17 publications

Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort

Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort

Everolimus for treatment of tuberous sclerosis complex‐associated neuropsychiatric disorders

Investigating the impact of innate dexterity skills and visuospatial aptitude on the performance of baseline laparoscopic skills in veterinary students

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