Gross Chemical Composition of the Two Sexes and Juveniles of Trichuris ovis

Kumar, Santosh

doi:10.2754/avb198756030297

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adults and mf of S . cervi have been analysed for various biochemical constituents (Rathaur et al , 1980; Malhotra et al , 1986; Kumar, 1987a, b). Both stages of the parasite are rich in protein, carbohydrate and lipids, while nucleic acids are detectable in only small amounts.…”

Section: Biochemical Compositionmentioning

confidence: 99%

Biochemical composition and metabolic pathways of filarial worms Setaria cervi: search for new antifilarial agents

Ahmad

Srivastava

2007

J. Helminthol.

View full text Add to dashboard Cite

The main problem regarding the chemotherapy of filariasis is that no safe and effective drug is available yet to combat the adult human filarial worms. Setaria cervi, the causal organism of setariasis and lumbar paralysis in cattle, is routinely employed as a model organism for conducting biochemical and enzymatic studies on filarial parasites. In view of the practical difficulties in procuring human strains of Wuchereria bancrofti and Brugia malayi for drug screening, the bovine filarial parasite S. cervi, resembling the human species in having microfilarial periodicity and chemotherapeutic response to known antifilarial agents, is widely used as a model in such studies. For a rational approach to antifilarial chemotherapy, knowledge of the biochemical composition and metabolic pathways of this helminth parasite may be of paramount importance, so that more potent antifilarial agents based on specific drug targets can be identified in drug discovery programmes. The present review provides an update on the biochemistry of the important metabolic pathways functioning within this potentially important bovine parasite, that have so far been studied, and on those that need to be investigated further so as to identify novel drug targets that can be exploited for designing new antifilarial drugs.

show abstract

Section: Biochemical Compositionmentioning

confidence: 99%