Gross jaw deformities in thalassaemia major

Jackson, Ian T.; Weel, F.; Crookendale, W. A.; McMichan, John C.

doi:10.1007/bf00295650

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Initial observational studies of the craniofacial complex of thalassaemia patients have shown that they are more prone to a Class II skeletal pattern (increased facial convexity with the mandible positioned posteriorly www.nature.com/scientificreports/ at the sagittal level in relation to the maxilla), without being able to define the exact structural differences from the normal population that could support their findings 10,11 . Further observational anthropometric studies are available 14,[32][33][34][35][36] , while 6 more studies [15][16][17][37][38][39] and one systematic review 40 could be found in the literature. These studies used conventional cephalometrics to compare beta thalassaemia patients with controls.…”

Section: Discussionmentioning

confidence: 99%

Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

Ρούσσος

Mitsea

Halazonetis

et al. 2021

Sci Rep

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The shape of the craniofacial complex of patients with beta thalassaemia was evaluated using geometric morphometrics on lateral cephalometric radiographs and was compared with matched controls. The beta thalassaemia group consisted of 40 patients (16 females, 24 males, mean age 33.4). Each patient was matched by age and gender to two controls (32 females, 48 males, mean age 33.1). The 120 lateral cephalometric radiographs were digitized and traced with 15 curves, 10 landmarks and 117 sliding semi-landmarks. These landmarks were subjected to Procrustes superimposition and principal component analysis in order to describe shape variability of the cranial base, maxilla and mandible, as well as of the entire craniofacial complex for each sex. The first 4 principal components accounted for 50% of the total sample’s variability. The beta thalassaemia group was significantly different in overall shape to the control group for both sexes. Similar findings were noted for the maxilla, the mandible and the cranial base. The main differences were related to smaller mandibular body for the thalassaemia group, midface protrusion and decrease in posterior face height. The shape of the craniofacial complex in these patients is prone to be more convex and hyperdivergent.

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Section: Discussionmentioning

confidence: 99%

Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

Ρούσσος

Mitsea

Halazonetis

et al. 2021

Sci Rep

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Skeletal, dentoalveolar, and soft tissue cephalometric measurements of Malay transfusion-dependent thalassaemia patients

Toman

Nasir²,

Hassan

et al. 2011

The European Journal of Orthodontics

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Thalassaemia is a public health problem in Malaysia. It is known to cause skeletal deformity. The purpose of this study was to compare the skeletal, dentoalveolar, and soft tissue features of Malay transfusion-dependent thalassaemia (TDT) patients with a Malay control group. Lateral cephalometric radiographs of 30 Malay (14 males and 16 females aged 6.4-21.8 years) TDT patients and 60 normal Malays matched for chronological age and gender were analysed and compared using an independent t-test. The TDT group showed a similar sagittal relationship to the control group but with a significantly increased (P < 0.01) mandibular plane inclination. They also showed a significantly shorter (P ≤ 0.001) mandibular body, ramus length, and posterior face height and consequently a smaller ratio of posterior to anterior face height (P < 0.01). The upper and lower lips were significantly procumbent (P < 0.001) in the TDT group together with a significantly smaller nasolabial angle (P < 0.05). Dentoalveolar measurements showed less proclined maxillary teeth in the TDT group compared with the controls (P < 0.05). The cephalometric features of Malay TDT patients were characterized by a mild Class II skeletal pattern, prominent vertical growth direction of the mandible, and protruded upper and lower lips.

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Craniofacial Deformities in Patients With Beta-Thalassemia: Orthodontic Versus Surgical Correction—A Systematic Review

Einy

Ben-Barak

Kridin

et al. 2019

Journal of Pediatric Hematology/Oncology

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Rapid blood cell turnover and bone marrow expansion caused by beta-thalassemia (βT) result in craniofacial and dentoalveolar anomalies. This report presents a systematic review of the literature over the past 50 years on orthodontic and surgical considerations in the management of βT-affected patients. Seventeen publications encompassed 24 patients, 11 male individuals and 13 female individuals, 7 to 43 years of age. Eleven patients underwent only surgical treatment, eleven combined orthodontic-surgical treatment, and 2 orthodontic treatment. Surgical treatment primarily addressed typical maxillary overgrowth by maxillary reshaping, premaxillary segmental repositioning, or complete Le Fort I impaction and set back osteotomy. In severe maxilla-mandibular discrepancy and/or increased lower facial height, a bilateral sagittal split mandibular osteotomy is the treatment of choice. Although surgery involves risks of excessive bleeding, morbidity, and impaired nasal esthetics, little attention is given to the orthodontic modality. In conclusion, the current literature recommends early interceptive orthodontics aimed to decrease dentoskeletal deformities, severe malocclusion, and soft tissue imbalance. Treatment includes maxillo-mandibular orthopedic and functional manipulation with dentoalveolar treatment, which might either prevent orthosurgical procedures later or reduce its extent. This suggested a multidisciplinary approach comprising a hematologist, a pediatrician, a pediatric dentist, and an orthodontist, which might also significantly improve the patient’s quality of life.

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Gross jaw deformities in thalassaemia major

Cited by 3 publications

References 6 publications

Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

Skeletal, dentoalveolar, and soft tissue cephalometric measurements of Malay transfusion-dependent thalassaemia patients

Craniofacial Deformities in Patients With Beta-Thalassemia: Orthodontic Versus Surgical Correction—A Systematic Review

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