Gross Morphological Study of Gestational Diabetes Mellitus Placenta From South Indian Mothers Compared With Control Placenta

P, Sharmila Bhanu; K, Devi Sankar; Kiran, Sujatha; Devi, Subhadra

doi:10.16965/ijar.2017.102

Cited by 5 publications

(5 citation statements)

References 24 publications

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“…[14][15][16] In the present study, the majority of women were in the agegroup of 31-35 years (45.7%) and 21-25 years (34.3%) in the case and control group, respectively. These observations were comparable with the results of the study conducted by Bhanu et al 17 In the study, 60 and 40% of study subjects were primigravida and multigravida, respectively. In a study conducted by Sheela et al, 72% were multiparous and 28% were primiparas.…”

Section: Discussionsupporting

confidence: 92%

“…25,26 In a study conducted by Bhanu et al, mean birth weight of the newborn babies was 2527 ± 516 gm in the control group and 3040 ± 464 gm in the GDM group which was highly significant (p < 0.0001). 17 In the current study, fetoplacental ratio was increased in the study group and similar observations were found in a study conducted by Hayward et al and Ahmed study. 17,27,28 In the present study, histological and morphological features observed in GDM pregnancies were comparable to other studies.…”

Section: Discussionsupporting

confidence: 91%

“…17 In the current study, fetoplacental ratio was increased in the study group and similar observations were found in a study conducted by Hayward et al and Ahmed study. 17,27,28 In the present study, histological and morphological features observed in GDM pregnancies were comparable to other studies. Insertion of the cord was marginal (68.6%) and central (28.6%) among cases.…”

Section: Discussionsupporting

confidence: 91%

“…23 Boyd et al noted that increased placental growth was the result of a concomitant metabolic or endocrine effect of hyperinsulinemia in diabetes. 24 The placental weight, volume, diameter, central thickness, and number of cotyledons were significantly more in GDM compared to control group in a study conducted by Bhanu et al 17 The present study showed that majority of the babies born to diabetic mothers had birth weight more than 4000 g and similar observations were noted in other studies. 25,26 In a study conducted by Bhanu et al, mean birth weight of the newborn babies was 2527 ± 516 gm in the control group and 3040 ± 464 gm in the GDM group which was highly significant (p < 0.0001).…”

Section: Discussionsupporting

confidence: 89%

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Morphological and Histopathological Features of Placenta in Women with Gestational Diabetes Mellitus and Its Association with Perinatal Outcome

Venkatesh,

Shetty,

Chaithra

2024

Journal of South Asian Federation of Obstetrics and Gynaecology

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Background: Placenta, a unique vascular organ, acts as a barrier between maternal and fetal circulation, protecting the fetus from adverse effects of maternal diseases. Gestational diabetes mellitus (GDM) alters the placental function leading to histological and morphological changes in placenta. Hyperglycemia affects placental development leading to adverse maternal and perinatal outcomes. Aim: To understand the morphological and histopathological variations of the placenta in GDM pregnancies and its association with the perinatal outcome. Materials and methods: A hospital-based cross-sectional study was conducted in women with singleton pregnancy between 37 and 40 weeks of gestation with GDM (Cases) and compared with women without GDM (Control). The morphological and histopathological features of the placenta were studied, and the associated perinatal outcome was analyzed. Results: In cases, most of the women had babies with birth weight of 3.51-4 kg (57.1%) and was statistically significant (p = 0.001). The mean placental weight among cases and controls was 719.57 ± 110. 8 gm and 380.71 ± 50.59 gm, respectively. Placental histopathological changes (calcification of the placenta, fibrinoid necrosis of villi and immature villous) were noted in cases and were statistically significant (p = 0.001). Abnormal perinatal outcomes were observed in cases with an oval-shaped placenta (64.7%), increased cord thickness (68.4%), fibrinoid necrosis of villi (50%), syncytial knots (61.9%), and immature villous (54.5%). Conclusion: Gestational diabetes mellitus causes an alteration in morphological and histological features of the placenta resulting in adverse perinatal outcomes. Early diagnosis, treatment, and glycemic control aid in reducing perinatal morbidity and mortality.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

See 2 more Smart Citations

Morphological and Histopathological Features of Placenta in Women with Gestational Diabetes Mellitus and Its Association with Perinatal Outcome

Venkatesh,

Shetty,

Chaithra

2024

Journal of South Asian Federation of Obstetrics and Gynaecology

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“…Biochemical and IHC analysis of the present study revealed the severe OS and the poor antioxidant capacity and thrive for the balance in the antioxidant system in GDM placental tissues. GDM is linked with fetal macrosomia [42], endothelial dysfunction associated with dyslipidemia, also known as hypertriglyceridemia, a positive correlation between maternal triglycerides and neonatal body weight [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Biochemical and Immunohistochemical Placental Antioxidant Status in Normal and Gestational Diabetes Mellitus Mothers

P¹,

K²,

Shanthi³

et al. 2017

IJAR

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Background and objectives: Gestational Diabetes Mellitus is associated with derangement of hormones, metabolites, and growth factors in maternal and fetal circulation which may influence the development and function of the placenta. The aim of this study were to compare oxidative stress and antioxidant system markers in GDM patients and normal subjects, and to determine the relationship between oxidative stress and GDM

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Gross Features of Human Placentae in Normal and Gestational Diabetes Mellitus

J¹,

Devi²

2021

jemds

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BACKGROUND Placenta is a multifunctional fetomaternal organ that plays an important role during pregnancy. Gestational diabetes mellitus (GDM) is reflected on placenta both macroscopically and microscopically as enlargement of placenta, abnormalities in villi and degenerative changes. METHODS This is a cross sectional study conducted among two groups, normal group and GDM group, to compare the gross features of GDM placentae in the Department of Obstetrics and Gynaecology and Department of Anatomy, Govt. Medical College, Thiruvananthapuram. RESULTS The study was conducted on 65 normal and 65 GDM placentae. There was an increased incidence of gestational diabetes mellitus in the age group > 25 years with a mean age of 26.38 ± 3.84 years. Multiparous women have been found to be more prone to gestational diabetes mellitus. Past history of abortions and intrauterine death (IUD) was more in GDM group as compared to normal group. Incidence of lower segment caesarean section (LSCS) was also more in GDM group. Weight, diameter and number of maternal cotyledons of placentae were significantly increased in GDM. The predominant shape of placenta in both groups was round, next to that was oval. Only 3 placentae showed irregular shape and that was from GDM group. Most common type of attachment of umbilical cord was eccentric in both groups. Next to that was central and marginal respectively. Only one placenta was furcate and that belonged to GDM group. Fetal membrane was translucent in all normal and GDM placentae. Mean birth weight of the baby of GDM mothers was significantly increased. Mean fetoplacental weight ratio was significantly decreased in GDM group as compared to normal group. CONCLUSIONS In the present study, GDM placentae showed significant changes in gross features. Meticulous gross examination of a placenta prior to histologic sectioning enhances microscopic interpretation. By increasing our understanding of the placenta, it may be possible to prevent and treat placental abnormalities related to GDM, thus ensuring lifelong health of the child and the mother. Hence, the present work would provide vital information to both obstetricians and neonatologists. KEY WORDS Placenta, Gestational Diabetes Mellitus, Morphology of Placenta

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Gross Morphological Study of Gestational Diabetes Mellitus Placenta From South Indian Mothers Compared With Control Placenta

Cited by 5 publications

References 24 publications

Morphological and Histopathological Features of Placenta in Women with Gestational Diabetes Mellitus and Its Association with Perinatal Outcome

Morphological and Histopathological Features of Placenta in Women with Gestational Diabetes Mellitus and Its Association with Perinatal Outcome

Evaluation of Biochemical and Immunohistochemical Placental Antioxidant Status in Normal and Gestational Diabetes Mellitus Mothers

Gross Features of Human Placentae in Normal and Gestational Diabetes Mellitus

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