Garden landscape not only provides people with places of rest and entertainment, but also protects the natural environment and maintained ecological balance. Although the traditional garden architectural style could retain the classical landscape style, the modern garden facilities and conditions had been greatly improved, and people’s expectations for the construction level of garden landscape continued to improve. Therefore, the effect of traditional landscape design could no longer meet the requirements of social development. This article proposed an interactive genetic algorithm-based landscape space environment optimization design method, in order to provide a certain theoretical reference for landscape design. Firstly, by analyzing the relationship between landscape and buildings, the change in people’s demand for landscape space environment and the relevant characteristics of landscape, this article expounded on the basic principles and methods that landscape design should follow and gave the problems existing in landscape design. Secondly, the interactive genetic algorithm and its innovative design theory were summarized, and the optimization design method of garden landscape space environment based on interactive genetic algorithm was proposed. Finally, the evaluation index system of landscape spatial environment was constructed, and experimental analysis was carried out with a landscape design as a case. The results showed that compared with the traditional landscape design methods, the design scheme proposed in this article could achieve better evaluation results. The optimization design method of landscape space environment proposed in this article could provide some technical support and theoretical reference for landscape architecture and design.