Groucho/TLE family proteins and transcriptional repression

Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells

“…The increased levels of Hes-1 could be due to the HDAC inhibiting effect of VPA, which would inhibit the repressive effect of RBP-Jk on Hes-1 expression, or alternatively by affecting other associated factors such as MAML. The decreased level of Hash-1, on the other hand, might seem more paradoxical since Hes-1 is known to repress transcription from the Hash-1 promoter by recruiting Groucho and HDAC, which is inhibited by VPA (Chen and Courey, 2000). It was however recently shown that Hes-1 could repress transcription of target genes by an additional, TSA insensitive, HDAC called SIRT.…”

Controlled levels of canonical Wnt signaling are required for neural crest migration

“…In the absence of Wnt signal Lef/Tcf acts as transcriptional repressors of Wnt target genes by forming a complex with several corepressors including myeloid translocation gene related-1 (Mtgr1) (Moore et al, 2008), corepressor of Pan (Coop) (Song et al, 2010), hydrogen peroxide-inducible clone (HIC5) (Ghogomu et al, 2006;Li et al, 2011) and the most intensively studied Groucho/transducin-like enhancer of split (Gro/TLE) repressor family Chen and Courey, 2000). Upon translocation of β-catenin to nucleus Lef/Tcf factors become converted into transcriptional activators and perform expression of the target genes (Daniels and Weis, 2005).…”

Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE

“…Paroush et al, 1994;Giagtzoglou et al, 2003). Drosophila Gro is the founding member of a family of highly conserved metazoan corepressors that associate with a myriad of transcription factors, rendering them transcriptional repressors (Chen and Courey, 2000). Notably, the vertebrate homologues of Gro -the Transducin-Like Enhancer of split (TLE) and the Gro-related gene (Grg) proteins -similarly play transcriptional regulatory roles in diverse developmental stages of higher organisms, including in neurogenesis (Fisher and Caudy, 1998;Chen and Courey, 2000).…”