Ground- and Triplet Excited-State Properties Correlation: A Computational CASSCF/CASPT2 Approach Based on the Photodissociation of Allylsilanes

Varras, Panayiotis C.; Zarkadis, Antonios K.

doi:10.1021/jp209583z

Cited by 2 publications

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References 74 publications

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“…Pearson was the first to point out the existence of a relation between the ground state bond strength (D 0 ) and excitation energy in diatomic molecules, in 1988 [57]. Since then this concept was extended to polyatomic molecules using a variety of quantum chemical methods showing not only relations between D 0 and the bond dissociation energy in an excited state (D 0 T1 : BDE in the first excited triplet state), but also relations concerning the activation energy in an excited state and the rate constant (k r ) of a photochemical reaction (e.g., D 0 T1 = α 1 + β 1 ∙D 0 or E a T1 = α 2 + β 2 ∙D 0 T1 ) [58,59,60]. This linear correlation between D 0 and D 0 T1 prompted us to study whether BDE may be used in our case as an indication for the cleavage ability, upon dissociation, of the oxime esters.…”

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confidence: 99%

Pyridine and p-Nitrophenyl Oxime Esters with Possible Photochemotherapeutic Activity: Synthesis, DNA Photocleavage and DNA Binding Studies

et al. 2016

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Compared to standard treatments for various diseases, photochemotherapy and photo-dynamic therapy are less invasive approaches, in which DNA photocleavers represent promising tools for novel "on demand" chemotherapeutics. A series of p-nitrobenzoyl and p-pyridoyl ester conjugated aldoximes, amidoximes and ethanone oximes were subjected to UV irradiation at 312 nm with supercoiled circular plasmid DNA. The compounds which possessed appropriate properties were additionally subjected to UVA irradiation at 365 nm. The ability of most of the compounds to photocleave DNA was high at 312 nm, whereas higher concentrations were required at 365 nm as a result of their lower UV absorption. The affinity of selected compounds to calf-thymus (CT) DNA was studied by UV spectroscopy, viscosity experiments and competitive studies with ethidium bromide (EB) revealing that all compounds interacted with CT DNA. The fluorescence emission spectra of the pre-treated EB-DNA exhibited a moderate to significant quenching in the presence of the compounds indicating the binding of the compounds to CT DNA via intercalation as concluded also by DNA-viscosity experiments. For the oxime esters the DNA photocleavage and affinity studies aimed to clarify the role of the oxime nature (aldoxime, ketoxime, amidoxime) and the role of the pyridine and p-nitrophenyl moieties both as oxime substituents and ester conjugates.

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