Ground-Glass Attenuation in Nodular Bronchioloalveolar Carcinoma: CT Patterns and Prognostic Value

Gaeta, Michele; Caruso, Rosario Alberto; Barone, Mario; Volta, S; Casablanca, G; Spada, Francesco La

doi:10.1097/00004728-199803000-00010

Cited by 45 publications

(14 citation statements)

References 17 publications

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“…As to histologic cell types and density distribution of the tumor, bronchioloalveolar carcinoma has been described to show ground-glass attenuation [12,13]. We noted the well-differentiated adenocarcinoma also to demonstrate ground-glass attenuation reflecting a lepidic growth pattern (type L1).…”

Section: Discussionmentioning

confidence: 68%

Small peripheral carcinomas of the lung: thin-section CT and pathologic correlation

et al. 1999

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The aim of this study was to clarify the thin-section CT features of small peripheral carcinomas of the lung on the basis of pathologic findings of tumor growth patterns. Thin-section CT and pathologic correlation was evaluated in 19 patients with surgically verified small peripheral carcinomas of the lung ( < 20 mm in size) that had been detected in a screening trial for lung cancer using spiral CT. Four thin-section CT types of nodules were observed: (a) type L1 (4 of 19, 21 %), a fairly well-defined nodule with ground-glass attenuation, corresponding to tumor lepidic growth without alveolar collapse; (b) type L2 (4 of 19, 21 %), a partly lobulated nodule with a low but inhomogeneous attenuation, corresponding to tumor lepidic growth with scattered foci of alveolar collapse; (c) type L3 (4 of 19, 21 %), an ill-defined nodule with an irregularly shaped higher-density central zone in a ground-glass attenuation peripheral zone, accompanied by convergence of the bronchovascular structures from the surrounding lung parenchyma, which corresponded to desmoplastic response in the central zone and to tumor lepidic growth in the peripheral zone; and (d) type H (7 of 19, 37 %), a well-defined nodule with a solid homogeneous attenuation, corresponding to tumor hilic growth. Thin-section CT features of small peripheral carcinomas of the lung can be classified into four types, based on the density distribution of the tumor, which reflect the histologic findings.

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Section: Discussionmentioning

confidence: 68%

Small peripheral carcinomas of the lung: thin-section CT and pathologic correlation

et al. 1999

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“…This second type of growth can be found with bronchioloalveolar carcinoma, which explains the ground-glass attenuation component that is commonly found with this type of tumor. In a series of 22 patients with bronchioloalveolar carcinoma, the halo sign was identified on CT images in two patients (16). In another series, which comprised 65 patients with lung metastases from extrapulmonary adenocarcinoma, the halo sign was present in two patients.…”

Section: Discussionmentioning

confidence: 97%

The CT Halo Sign

Pinto¹

2004

Radiology

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“…5). Recently, a close correlation was established between CT diagnoses of ground-glass SPNs and the histological findings of adenocarcinoma: the ground-glass component in adenocarcinomas is associated with lepidic growth or mucin production [19,22], and its possible predominance over the solid component is related to prognosis. Aoki et al showed that a predominance of solid alveolare di adenocarcinoma [6,19].…”

Section: Cavitation and Ground-glass Opacitymentioning

confidence: 99%

“…5) [21]. Recentemente si è giunti a definire una stretta corrispondenza tra le diagnosi TC di NPS a vetro smerigliato ed il corrispettivo istologico di adenocarcinoma: la componente a vetro smerigliato negli adenocarcinomi è associata alla crescita lepidica o alla produzione di mucina [19,22] e la sua preponderanza o meno rispetto alla componente solida è correlata alla prognosi. Infatti, Aoki et al [23] hanno evidenziato che la maggior presenza della componente solida nel contesto di NPS ground-glass è associata ad un comportamento maggiormente invasivo (tipi C, D, E, F della classificazione Noguchi, ovvero, rispettivamente, carcinomi bronchioloalveolari con presenza di proliferazione fibroblastica, carcinomi poco differenziati, tubulari e papillari, con un pattern di crescita di tipo compressivo) [23,24].…”

Section: Cavitation and Ground-glass Opacityunclassified

Nodulo polmonare: caratteristiche clinico-radiologiche che possono influenzare la diagnosi di malignità

et al. 2009

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The role of computed tomography (CT) in the diagnosis of the solitary pulmonary nodule (SPN) is constantly expanding. CT helps to detect a growing number of increasingly small lesions, but, as with chest radiography, the primary goal in the evaluation of small pulmonary nodules is to exclude malignancy. Despite the availability of numerous, variously invasive, diagnostic tests, diagnostic accuracy tends to decline as the size of the nodule decreases. The role of the radiologist is therefore to help the clinician determine the most appropriate management strategy by using all available modalities [CT, magnetic resonance (MR) imaging, positron emission tomography (PET)] and evaluating the patient's clinical history and the imaging features leading to a diagnosis of benignity or malignancy. Imaging features include nodule size, margins, calcifications and fatty component, internal features (cavitations, pseudocavitations, air bronchogram, halo sign), as well as advanced techniques for characterisation (growth rate, contrast enhancement) and management (computer-aided diagnosis, Bayesian analysis, neural networks). The aim of this paper is to summarise the approach to pulmonary nodules from the point of view of the radiologist, oncologist and thoracic surgeon.

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Ground-Glass Attenuation in Nodular Bronchioloalveolar Carcinoma: CT Patterns and Prognostic Value

Cited by 45 publications

References 17 publications

Small peripheral carcinomas of the lung: thin-section CT and pathologic correlation

Small peripheral carcinomas of the lung: thin-section CT and pathologic correlation

The CT Halo Sign

Nodulo polmonare: caratteristiche clinico-radiologiche che possono influenzare la diagnosi di malignità

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