Since Einstein’s prediction regarding the existence of gravitational waves was directly verified by the ground-based detector Advanced LIGO, research on gravitational wave detection has garnered increasing attention. To overcome limitations imposed by ground vibrations and interference at arm’s length, a space-based gravitational wave detection initiative was proposed, which focuses on analyzing a large number of waves within the frequency range below 1 Hz. Due to the weak signal intensity, the TMs must move along their geodesic orbit with a residual acceleration less than 10−15 m/s2/Hz1/2. Consequently, the core payload-inertial sensor was designed to shield against stray force noise while maintaining the high-precision motion of the test mass through a drag-free control system, providing an ultra-stable inertial reference for laser interferometry. To meet these requirements, the inertial sensor integrates a series of unit settings and innovative designs, involving numerous subsystems and technologies. This article provides a comprehensive overview of these critical technologies used in the development of inertial sensors for space gravitational wave detection and discusses future trends and potential applications for these sensors.