Following the 2016 Leave vote in the referendum on UK membership in the EU and the election of Donald Trump, trade agreements have entered a period of great instability. To predict the impact of possible disruptions to existing arrangements requires counterfactual analysis that takes into account the complex set of factors influencing the production and marketing strategies of multinational corporations. We estimate a model of multinational decision-making in the car industry. This model predicts the production reallocation and consumer surplus consequences of changes in tariffs and non-tariff barriers induced by US-led protectionism, Brexit, transpacific, and transatlantic integration agreements. (JEL F13, F23, L21, L62, M31)After decades in which free trade agreements proliferated and deepened in scope, 2016 appeared to mark a major turning point. The Leave vote in the UK referendum on EU membership and the election of Donald Trump brought long-standing integration arrangements to the brink of disruption. Pure trade models are ill-equipped for predicting the outcomes of regional dis-integration because they omit an increasingly important feature of the world economy: multinational production (MP). The foreign affiliate structures of multinational corporations (MNCs) complicate matters because they introduce new sets of bilateral relationships. In addition to the origin-destination goods flows of standard trade models, MP models feature interactions between headquarters and subsidiary locations. MNCs must decide which of their network of production facilities will serve each market. Furthermore, because MNCs are typically multiproduct firms, they face decisions over which subset of varieties to offer in each of the markets where they choose to operate distribution facilities. Each of these decisions is likely to be influenced by distinct bilateral frictions.