Groundwater arsenic contamination: impacts on human health and agriculture, ex situ treatment techniques and alleviation

Patel, Bhavi; Gundaliya, Rohan; Desai, B.O.; Shah, Manan; Shingala, Jainish; Kaul, D. S.; Kandya, Anurag

doi:10.1007/s10653-022-01334-5

Cited by 8 publications

(2 citation statements)

References 129 publications

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“…Arsenic contamination is a serious environmental and geochemical issue endangering human health [1]. Exposure to inorganic arsenic compounds cause not only skin lesions, kidney damage, and peripheral nervous system injury but also liver injury, liver fibrosis, cirrhosis, and liver cancer [2].…”

Section: Introductionmentioning

confidence: 99%

PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis

Huang¹,

Ding²,

Yuan³

et al. 2023

Preprint

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Background: Exposure to inorganic arsenic (iAs) remains a global public health problem. The liver is the main target organ of arsenic, leading to arsenic-induced liver fibrosis. Autophagy is involved. Phosphatase and tensin homology deleted on chromosome ten (PTEN) may participate in arsenic-induced liver fibrosis by regulating autophagy, but the exact mechanisms remain unclear. We established a mouse model of arsenic poisoning through the drinking water, and a fibrosis model using the huma stellate cell (HSC) line LX-2, which was exposed to NaAsO2 for 24h. HE and Masson staining was adopted to observe the degree of liver fibrosis. The cells were transfected using PTEN overexpression plasmid. Western blot and qRT-PCR were used to determine the levels of protein/mRNA expression. The in vivo results were confirmed in HSCs exposed to NaAsO2, with changes suggesting fibrosis as seen in mice. NaAsO2 upregulated the expression of the autophagic markers microtubule-associated protein light chain A/B (LC3), recombinant human autophagy effector protein (Beclin-1), hairy and enhancer of split homolog-1 (HES1), but downregulated PTEN. α-smooth muscle actin (α-SMA) expression was significantly upregulated in all NaAsO2 groups. PTEN overexpression altered NaAsO2-induced autophagy which LC3, Beclin-1 were downregulated. Notch1, HES1, α-SMA, and collagenⅠexpression were all downregulated in the NaAsO2 groups. In conclusion, PTEN overexpression might decrease autophagy and inhibit fibrosis progression caused by this toxin. The NOTCH1/HES1 pathway is likely to be involved in this process. Most previous studies did not investigate PTEN and arsenic-induced liver fibrosis specifically. The present study highlights the importance of targeting PTEN for the management of arsenic exposure.

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Section: Introductionmentioning

confidence: 99%

PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis

Huang¹,

Ding²,

Yuan³

et al. 2023

Preprint

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“…Natural and anthropogenic activities such as coal and ore mining and use of arsenical compounds in agriculture contributed largely to arsenic (As) contaminations of agricultural soils (Dubey et al, 2022 ; Mandal & Suzuki, 2002 ; Smith et al, 1998 ). In alkaline agricultural soils, solubility of As enhances and its high leaching potential through soil profile triggers contamination of groundwater and surface waters that present a constant danger to population health (Niazi et al, 2011 ; Patel et al, 2022 ; Smith & Steinmaus, 2009 ; Yuan et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Potential use of nanoparticles produced from byproducts of drinking water industry in stabilizing arsenic in alkaline-contaminated soils

Moharem

Hamadeen

Mesalem

et al. 2023

Environ Geochem Health

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The stabilization of heavy metals in soils is considered a cost-effective and environmentally sustainable remediation approach. In the current study, the applicability of water treatment residual nanoparticles (nWTRs) with the particle size ranged from 45 to 96 nm was evaluated for its efficacy in reducing arsenic mobility in clayey and sandy contaminated alkaline soils. Sorption isotherms, kinetics, speciation and fractionation studies were performed. Sorption equilibrium and kinetics studies revealed that As sorption by nWTRs-amended soils followed Langmuir and second-order/power function models. The maximum As sorption capacity (qmax) of Langmuir increased up to 21- and 15-folds in clayey and sandy soils, respectively, as a result of nWTRs application at 0.3% rate. A drastic reduction in non-residual (NORS) As fraction from 80.2 and 51.49% to 11.25 and 14.42% for clayey and sandy soils, respectively, at 0.3% nWTRs application rate was observed, whereas residual (RS) As fraction in both studied soils strongly increased following nWTRs application. The decline in percentage of As mobile form (arsenious acid) in both soils after nWTRs application indicated the strong effect of nWTRs on As immobilization in contaminated soils. Furthermore, Fourier transmission infrared spectroscopy analysis suggested reaction mechanisms between As and the surfaces of amorphous Fe and Al oxides of nWTRs through OH groups. This study highlights the effective management approach of using nWTRs as soil amendment to stabilize As in contaminated alkaline soils.

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Can mobile wallet usage contribute towards environmental sustainability? Evidence from a moderated mediation approach

Katini,

Amalanathan,

Hriizhiinio

2023

Univ Access Inf Soc

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Groundwater arsenic contamination: impacts on human health and agriculture, ex situ treatment techniques and alleviation

Cited by 8 publications

References 129 publications

PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis

PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis

Potential use of nanoparticles produced from byproducts of drinking water industry in stabilizing arsenic in alkaline-contaminated soils

Can mobile wallet usage contribute towards environmental sustainability? Evidence from a moderated mediation approach

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