Like several parts in the Middle East, the West Bank is in a significant water scarcity status. Palestinians use groundwater as the main water source, supplying more than 90% of the consumed water in the West Bank. e aim of this study is to enhance the knowledge on drinking water quality in the West Bank. Groundwater quality data was obtained from the Palestinian Water Authority, including the years 2015 and 2016, from the Northern six districts of the West Bank. e water quality data were analyzed and matched with the World Health Organization (WHO) guidelines and the Palestinian standards for drinking water quality. e findings of this study revealed that groundwater in the north of the West Bank comply with several drinking water requirements including total hardness, pH, and sodium and chloride content. Conversely, 18% of the samples exceed the limits for nitrate concentration. e fecal Coliforms and total Coliforms results show that 98.7% of the samples give no risk, but 1.3% of the samples give low risk, and no sample gives intermediate-to-high risks. e microbial and chemical pollution of groundwater is postulated to inadequate wastewater management, high use of fertilizers, and uncontrolled disposal of animal manure. erefore, it is crucial to disinfect drinking water at the source of production before supply as an immediate action, followed by implementing pollution prevention measures.