2018
DOI: 10.1096/fasebj.2018.32.1_supplement.819.6
|View full text |Cite
|
Sign up to set email alerts
|

Group A Streptococcus Prevents Lysosomal Acidification in THP‐1 Macrophages By Inhibiting V‐ATPase Complex Fformation

Abstract: Group A Streptococcus (GAS) is a Gram‐positive bacterial pathogen responsible for approximately 750 million human‐specific infections worldwide every year, ranging in severity from mild pharyngitis to necrotizing fasciitis. To defend against invasive pathogens such as GAS, the innate immune system deploys macrophages to phagocytose and eradicate the bacterial pathogen via engulfment into the phagosome, fusion with lysosomes, phagosomal acidification, and activation of hydrolytic enzymes. We have demonstrated t… Show more

Help me understand this report

This publication either has no citations yet, or we are still processing them

Set email alert for when this publication receives citations?

See others like this or search for similar articles