Group B Streptococcal Disease in Nonpregnant Patients: Emergence of Highly Resistant Strains of Serotype Ib in Taiwan in 2006 to 2008

Abstract

Among the 228 group B Streptococcus (GBS) isolates recovered in 2006 to 2008, higher resistance to erythromycin (58.3%) and clindamycin (57.9%) was found in isolates with certain resistance phenotypes. Serotype Ib isolates (24.6%) were the second most prevalent serotype, next to serotype V (29.4%), and showed the highest resistance rates to erythromycin (91.0%) and clindamycin (82.1%).

Serotype distribution, antimicrobial resistance, and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates

“…The incidence of erythromycin resistance was 92.5%. This is higher when compared with Taiwan (58.3%) and western countries, ranging from 11.5% to 32% [24][25][26][27]. Last, the nonsusceptible rate to clindamycin reported here was higher than that in Korea (54.0%) [28] and the US (38.4%) [29].…”

Serotype distribution and resistance genes associated with macrolide and fluoroquinolone resistance in Streptococcus agalactiae isolates from a hospital in southern Taiwan

“…In a previous study, we determined that the predominant ERY/CLI resistance phenotype was iMLS B in serotype Ib and cMLS B in serotypes III and V. [19] The prevalent resistance genes vary between countries, with ermB, ermTR, and mefA being prevalent in Spain and the USA [26] and ermB and lnuB being prevalent in Korea. [25] The association of the erm and mef drug resistance genes with drug resistance phenotype and serotype was seldom reported.…”

“…agalactiae is a zoonotic pathogen of fish, bovines, and humans. [19,21,22] Most GBS isolates were collected from female patients. [19] The predominant human serotype differs between countries, with serotype V being the primary serotype in the USA, [21,23] serotype III in France and Zimbabwe, and serotypes III and V being the primary serotypes in Korea.…”

“…[19,21,22] Most GBS isolates were collected from female patients. [19] The predominant human serotype differs between countries, with serotype V being the primary serotype in the USA, [21,23] serotype III in France and Zimbabwe, and serotypes III and V being the primary serotypes in Korea. [16,24,25] In this study, although the total number of GBS isolates decreased from 2007 to 2008, the predominant serotypes varied.…”

“…[13,[16][17][18] Recently, we reported highly erythromycin/clindamycin-resistant phenotypes in different serotypes, with constitutive macrolide-lincosamide-streptogramin B (cMLS B ) as the most prevalent resistance type, followed by inducible macrolide-lincosamide-streptogramin B (iMLS B ), macrolide (M), and lincosamide-streptogramin A (LSA). [19] In this study, we investigated the prevalence of ermB and mefE and the association of these genes with different serotypes and antimicrobial resistance. Mutations in the QRDR region of GyrA and ParC in fluoroquinolone-resistant GBS isolates were also determined.…”