Group B streptococcal disease in the mother and newborn—A review

Steer, Philip; Russell, Alison; Kochhar, Sonali; Cox, Philippa; Plumb, Jane A.; Rao, G. Gopal

doi:10.1016/j.ejogrb.2020.06.024

Cited by 30 publications

(33 citation statements)

References 83 publications

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“…Group B Streptococcus (GBS) is a fast‐growing gram‐positive bacterium which commonly colonizes the upper respiratory tract, as well as the gastrointestinal and genitourinary tract of approximately 30% of asymptomatic adults (Murray et al, 2016). During pregnancy, GBS can increase the risk of urinary tract infection, chorioamnionitis, endometritis and sepsis, featuring as a risk factor for miscarriage, preterm labour and stillbirth (Steer et al, 2020). Typically colonizing a pregnant woman's intestinal and/or genitourinary tract, GBS can spread to the amniotic fluid, placenta, cervix or vagina (Heath & Jardine, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Typically colonizing a pregnant woman's intestinal and/or genitourinary tract, GBS can spread to the amniotic fluid, placenta, cervix or vagina (Heath & Jardine, 2014). The foetus can then acquire the bacteria either in‐utero via vertical transmission during labour (even with membranes intact) or during vaginal birth (Steer et al, 2020). Invasive Early‐Onset Group B Streptococcus Disease (EOGBSD), which occurs from 0 to 7 days of life, can result leading to serious complications for neonates including meningitis, pneumonia and neonatal sepsis, where it continues to be a major cause of morbidity and mortality among term and preterm neonates (HogenEsch et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Adherence to screening and management guidelines of maternal Group B Streptococcus colonization in pregnancy

Pangerl

Sundin

Geraghty

2022

Journal of Advanced Nursing

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Aims To investigate Group B Streptococcus (GBS) colonization in pregnancy; adherence to antenatal GBS screening and adherence to the intrapartum antibiotics protocol within two models of care (midwifery and non‐midwifery led). Design This retrospective quantitative study has employed a descriptive design using administrative health data. Methods Data from five maternity hospitals in metropolitan and regional Western Australia that included 22,417 pregnant women who gave birth between 2015 and 2019 were examined, applying descriptive statistics using secondary data analysis. Results The study revealed an overall GBS colonization rate of 21.7% with similar rates in the different cohorts. A lower adherence to screening was found in the midwifery led model of care (MMC, 68.76%, n = 7232) when compared with the non‐midwifery led model of care (NMMC, 90.49%, n = 10,767). Over the 5 years, screening rates trended down in the MMC with stable numbers in the counterpart. Adherence in relation to intrapartum antibiotic prophylaxis revealed discrepant findings between the study groups. Conclusion Adherence to screening and management guidelines of maternal GBS colonization in pregnancy is lower within the MMC when compared with the NMMC. Impact This is the first cohort study to describe the adherence to the recommended Western Australian GBS screening guidelines in the two different models of care. Findings may assist in the guidance and improvement of clinical protocols as well as the planning of clinical care in relation to GBS screening to reduce the risk of neonatal GBS infection.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adherence to screening and management guidelines of maternal Group B Streptococcus colonization in pregnancy

Pangerl

Sundin

Geraghty

2022

Journal of Advanced Nursing

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“…Group B Streptococcus (GBS) is an important cause of infection in maternal and neonatal in many countries in the world (15,16). The most important risk factor of the infectious disease in the neonatal in developing countries was maternal GBS colonization (17). The strategy of prevention and control of GBS related diseases is data collection in different populations, but there are still little data from Vietnam.…”

Section: Discussionmentioning

confidence: 99%

High Rates of Streptococcus Agalactiae Clindamycin and Erythromycin Resistance in Vietnamese Pregnant Women

Du¹,

Dung²,

Toàn³

et al. 2021

Preprint

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Background Group B streptococcus (GBS) is a leading cause of morbidity and mortality in newborns. Maternal GBS colonization rates vary depending on geographic area, ethnic and social conditions worldwide. Many studies suggested the continuous surveillance of GBS to provide data to guide decision-making and planning prevention and control strategies. Here, we report the rate and the antimicrobial susceptibility pattern of GBS from Vietnamese pregnant women over 5 year period. Methods We worked with 3863 Vietnamese pregnant women at < 37 weeks of gestation at the National Hospital of Obstetrics and Gynecology, Hanoi, Vietnam from Jan 2016 to Dec 2020. The data were recorded and retrieved from the computerized laboratory database. GBS was identified according to the American Society for Microbiology’s guidelines. Antimicrobial susceptibility was tested by the VITEK 2 system or E-test strips. The results were calculated according to the MIC breakpoints recommended by the Clinical and Laboratory Standards Institute. Results The positivity for GBS was 8.02% (310/3863) and the highest resistance rate was to tetracycline 89.66% (234/261), followed by 76.23% (202/265) for erythromycin, 58.21% (156/268) for clindamycin. The multidrug-resistance rate was 59.19% (161/272), and 8.46% (23/272) of isolates were resistant to 6 to 7 of the 12 antibiotics. Resistance to clindamycin in the absence of erythromycin resistance was found in 6/272 (2.2%) samples. The resistance rate to clindamycin was significantly increased (p < 0.01) over the time study period. Nevertheless, all isolates were sensitive to penicillin, ampicillin, ceftriaxone, cefotaxime, quinupristin/dalfopristin, and vancomycin. Conclusion Our results indicate that penicillin and ampicillin are currently the drugs of choice for the prevention and treatment of GBS-related diseases for Vietnamese pregnant women. However, antibiotic resistance to erythromycin and clindamycin was high. Thus, it reinforces the need for continuous surveillance of GBS to provide data to guide planning prevention and control strategies.

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“…Group B Streptococcus (GBS) is a leading cause of maternal, fetal and neonatal morbidity and mortality worldwide, being associated with 3.5 million preterm births, 319,000 neonatal infections and 147,000 neonatal deaths annually (Seale et al, 2017;Steer et al, 2020). Asymptomatic anovaginal colonization of pregnant women is the main risk factor for neonatal GBS infections, which are usually derived from vertical transmission.…”

Section: Words: 802mentioning

confidence: 99%

Group B Streptococcus awareness month: vaccine and challenges underway

Pinto

Oliveira

Costa

et al. 2021

International Journal of Infectious Diseases

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Group B streptococcal disease in the mother and newborn—A review

Cited by 30 publications

References 83 publications

Adherence to screening and management guidelines of maternal Group B Streptococcus colonization in pregnancy

Adherence to screening and management guidelines of maternal Group B Streptococcus colonization in pregnancy

High Rates of Streptococcus Agalactiae Clindamycin and Erythromycin Resistance in Vietnamese Pregnant Women

Group B Streptococcus awareness month: vaccine and challenges underway

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