Group B Streptococcal Endocarditis: Report of Seven Cases and Review of the Literature, 1962-1985

Streptococcus agalactiae left-sided infective endocarditis. Analysis of 27 cases from a multicentric cohort

“…Thus, surgery is frequently required 4e11 and a high mortality (range: 35%e50%) has been reported in recent years. 2,5,9,10 We have analyzed all cases of left-sided IE due to this pathogen in our cohort for reevaluating these aspects and a comparison with other streptococci and enterococcal IE is made.…”

FbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation

“…19 Cases of S agalactiae-induced endocarditis in adults have been reported more frequently in recent years and are usually associated with predisposing conditions such as alcoholism and diabetes mellitus although endocarditis caused by S agalactiae in healthy adults has also been described. [20][21][22][23] S agalactiae strains, possessing Fbg-binding activity, were previously shown to induce platelet aggregation and to be involved in disseminated intravascular coagulation in mice. 24 Because crude extracts of S agalactiae strains, exhibiting significant Fbg-binding activity, were able to inhibit platelet aggregation, it was suggested that the Fbg-binding activity of S agalactiae participates in platelet aggregation.…”

Unsuspected rheumatic heart underlying group B streptococcal endocarditis at the age of 20 months

“…Worthy of note is the isolation of GBS as the aetiological agent of the EC, a rare pathogen in this kind of infection in children [1,22]. Its invasive p o w e r has also b e e n r e p o r t e d regarding valvular destruction, m y o c a r d i a l involvement, mycotic aneurysm d e v e l o p m e n t and m o r t a l i t y rate [1,8,13]. A r e m a r k a b l e finding was the f o r m a t i o n of an infective sinus of Valsalva p s e u d oaneurysm, an infrequent c o m p l i c a t i o n of bacterial EC, particularly in chidren [1,10,20].…”