Group B streptococcal infection presenting as sudden death in infancy.

Sudden unexplained death in childhood (SUDC) is rare, with a reported incidence in the United States of 1.5 deaths per 100,000 live births compared with 56 deaths per 100,000 live births for sudden infant death syndrome in 2001. The objectives of this study include a proposal for a general definition for SUDC and presentation of 36 cases of SUDC and 14 cases of sudden unexpected death in childhood. Cases were accrued through referrals or unsolicited via our Web page (http://www.sudc.org ). Our analyses tentatively suggest a SUDC profile characterized by cases being 1 to 3 years in age, predominantly male, and frequently having a personal and family history of seizures that are often associated with a fever. A history of recent minor head trauma is not uncommon. They are usually born at term as singletons and occasionally have a family history of sudden infant death syndrome or SUDC. Most are found prone, often with their face straight down into the sleep surface. Minor findings are commonly seen at postmortem examination but do not explain their deaths. Comprehensive review of the medical history and circumstances of death and performance of a complete postmortem examination including ancillary studies and extensive histologic sampling of the brain are critical in determining the cause of death in these cases of sudden unexpected childhood death. Legislation enabling research and formation of a multicenter research team is recommended to unravel the mystery of SUDC.

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Sudden Unexpected Death in Childhood: A Report of 50 Cases

Krous

et al. 2005

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Invasive streptococcal infections in the era before the acquired immune deficiency syndrome: A 10 years' compilation of patients with streptococcal bacteraemia in North Yorkshire

Barnham

1989

Journal of Infection

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Overwhelming sepsis presenting as sudden unexpected death.

Sharief

Khan

Conlan

1993

Archives of Disease in Childhood

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A previously well baby was found to be snuffly at the routine check at 6 weeks of age. Two weeks later, over a 24 period she was reluctant to feed and early that morning she woke up screaming and crying. Suddenly she became limp and cyanotic. She was resuscitated by her parents and taken to hospital where she was found to be dead on arrival.Postmortem examination showed the trachea to contain some frothy fluid. The lungs were congested with subpleural petechial haemorrhages in the interlobular fissures; no other abnormalities were found. Microbiology confirmed group A ,1 haemolytic streptococcus (GABHS) from the blood, lungs, and heart. The pathologist felt that the cause of death was acute bronchiolitis.

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Group B streptococcal infection presenting as sudden death in infancy.

Cited by 5 publications

References 2 publications

Sudden Unexpected Death in Childhood: A Report of 50 Cases

Sudden Unexpected Death in Childhood: A Report of 50 Cases

Invasive streptococcal infections in the era before the acquired immune deficiency syndrome: A 10 years' compilation of patients with streptococcal bacteraemia in North Yorkshire

Overwhelming sepsis presenting as sudden unexpected death.

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