Group B Streptococcal Meningitis: A Description of Six Case Reports

Coni, Elisabetta; Marcialis, Maria Antonietta; Pintus, Maria Cristina; Irmesi, Roberta; Masile, Valentina; Fanos, Vassilios

doi:10.14740/ijcp179w

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Focal ischemic changes were present in only 2 patients; both had left middle cerebral artery stroke. In addition, 3 children in our group had cerebral sinus venous thrombosis, which was also reported in one patient in a case series by Coni et al, 33 who also described 2 patients with bilateral subdural effusions/empyema, which is similar to our findings.…”

Section: Discussionsupporting

confidence: 91%

Neonatal Group B Streptococcal Meningitis: Predictors for Poor Neurologic Outcome at 18 Months

et al. 2021

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Aim To find early predictors for poor neurodevelopmental outcome after neonatal group B streptococcal meningitis. Methods We retrospectively analyzed clinical characteristics of 23 patients with neonatal group B streptococcal meningitis and their neurodevelopmental outcome at 18 months. Available group B Streptococcus strains were serotyped and their genomes characterized. Results We found several differences between patients with early- (n = 5) and late-onset (n = 18) disease. Nine children had neurologic abnormalities at 18 months and 4 had epilepsy, all of them after late-onset disease. Most important risk factors for poor outcome were impaired consciousness at admission, hemodynamic instability, seizures, or abnormal electroencephalogram during the acute illness and abnormal neurologic and ophthalmologic examination at the end of treatment, whereas abnormalities in laboratory and imaging studies were not predictive. Hypervirulent serotype III, multilocus sequence type 17 group B Streptococcus was the predominant pathogen. Conclusions Neurodevelopmental impairment after neonatal group B streptococcal meningitis is likelier in those with clinical and neurophysiological features indicating worse disease severity.

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Section: Discussionsupporting

confidence: 91%

Neonatal Group B Streptococcal Meningitis: Predictors for Poor Neurologic Outcome at 18 Months

et al. 2021

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“…Therefore, pregnant women who carry GBS can transfer it to their infants. About half of the infants born from carrier mothers have no symptoms at birth; however, 1% of them have invasive infections such as sepsis, meningitis, pneumonia, septic arthritis, among others (8). In the case of the present study, the GBS screening was not performed on the mother.…”

Section: Discussionmentioning

confidence: 91%

Early-Onset Meningitis with Group B Streptococcus: The Case of a Female Neonate with Brain Abscess in Iran

Mosayebi

Mohammadi

et al. 2017

J Compr Ped

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Introduction: Group B streptococcus (GBS) is a leading cause of neonatal sepsis and meningitis. Although late-onset GBS meningitis is the most common form of the disease, it may happen earlier, like just a few hours after birth, known as the early-onset. GBS meningitis is associated with 30% mortality rate among infants. Of those who stay alive, 25% of them will develop adverse neurological conditions. Herein, we report a case of early-onset GBS meningitis in a female infant with brain abscess. Case Presentation: A 10-hour old female was admitted to the neonatal intensive care unit (of the University of Tehran) for poor feeding, irritability, lethargy, and seizure. Sepsis work-up and lumbar puncture were performed. The treatment was started with vancomycin, cefotaxime and phenobarbital. The GBS was isolated from both blood and CSF cultures. A cranial sonography revealed intraparenchymal hemorrhage. The infant's hospital course was complicated by recurrent and intractable seizures. The brain MRI of the patient showed micro-abscess. After six weeks of medical therapy, the patient was discharged from the hospital in a good condition. Neurological evaluations of the patient, conducted two and five months after her birth, showed normal results. Conclusions: Neonates with GBS meningitis are prone to adverse neurological conditions, including brain abscess. Although GBS is a normal flora in the genitourinary tracts of 15 to 30% of women, routine screening and treatments of the GBS-positive women during their course of pregnancy could reduce such serious complications.

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“…Streptococcus agalactiae, categorized in group B Streptococcus, is the most common microorganism causing purulent meningitis among neonates or infants younger than 90 days [124][125][126]. Figure 43 displays Gram-positive cocci phagocytized by neutrophils in the cerebrospinal fluid of a neonate.…”

Section: Purulent Meningitis In the Neonate Caused By Group B Strepto...mentioning

confidence: 99%

Pathology of Streptococcal Infections

Tsutsumi¹

2022

Antibiotic Resistance - New Insights [Working Title]

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Streptococcus pyogenes and Streptococcus pneumoniae, representative Gram-positive cocci, may cause both localized (skin and soft tissue) and systemic infections. Lobar pneumonia is a unique form of acute and severe lung infection of S. pneumoniae. Streptococcus viridans group, normal flora of the oral cavity, may lead not only to mucosal infection but also to aspiration pneumonia, infective endocarditis, and systemic infections. The severest and often lethal form of progressive and systemic infection includes fulminant streptococcal and pneumococcal infections. Autopsy is essentially important for the analysis of fulminant infections. Pathological features of varied streptococcal infections are illustrated and discussed. Immunohistochemical identification of the pathogen in formalin-fixed, paraffin-embedded sections is effective and valuable in confirming the type of infected pathogens.

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Group B Streptococcal Meningitis: A Description of Six Case Reports

Cited by 3 publications

References 15 publications

Neonatal Group B Streptococcal Meningitis: Predictors for Poor Neurologic Outcome at 18 Months

Neonatal Group B Streptococcal Meningitis: Predictors for Poor Neurologic Outcome at 18 Months

Early-Onset Meningitis with Group B Streptococcus: The Case of a Female Neonate with Brain Abscess in Iran

Pathology of Streptococcal Infections

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