Group B Streptococcal Neonatal Meningitis

Tavares, Teresa; Pinho, Liliana; Andrade, Elva Bonifácio

doi:10.1128/cmr.00079-21

Cited by 39 publications

(30 citation statements)

References 275 publications

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“…Although the type III CC17 GBS strain is known to have caused the majority of neonatal invasive diseases in recent decades ( 8 – 10 , 12 , 13 ), the type Ib CC12 GBS strain has been found to be more virulent and fatal than the type III CC17 strain ( 20 , 22 , 24 , 26 ). Recent reports found a mortality rate of 30.8% in neonates with type Ib CC12 GBS invasive disease ( 24 ), which was much higher than the reported 8.8 to 12% mortality rate associated with GBS invasive diseases caused by other serotypes, including a mortality rate of 12.5 to 18.5% associated with the type III CC17 GBS strain ( 8 – 10 , 12 , 13 , 27 – 29 ). Zhang et al and others also found that type Ib CC10 GBS isolates were associated with a significantly higher rate of meningitis and higher illness severity ( 20 – 22 ).…”

Section: Discussionmentioning

confidence: 75%

Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics

et al. 2023

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Section: Discussionmentioning

confidence: 75%

Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics

et al. 2023

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“…Many brain cells can produce cytokine and pro-inflammatory proteins when bacterial enter the CSF, these pro-inflammatory proteins include reactive oxygen species (ROS), nitric oxide, peroxynitrite, matrix metalloproteinases (MMPs), platelet activating factor, calcium, etc ( 25 , 26 ). A comparison of BM group with N group, GO analysis showed that the signal pathways that involve these pro-inflammatory proteins in active states in our data.…”

Section: Discussionmentioning

confidence: 99%

Quantitative proteomics on the cerebrospinal fluid of hydrocephalus in neonatal bacterial meningitis

Chen

Huang

Zhang³

et al. 2022

Front. Pediatr.

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ObjectiveHydrocephalus in bacterial meningitis (BM) is a devastating infectious neurological disease and the proteins and pathways involved in its pathophysiology are not fully understood.Materials and methodsLabel-free quantitative (LFQ) proteomics analyses was used to identify differentially expressed proteins (DEPs) in cerebrospinal fluid (CSF) samples from infants with hydrocephalus and bacterial meningitis (HBM group, N = 8), infants with bacterial meningitis (BM group, N = 9); and healthy infants (N group, N = 11). Bioinformatics analysis was subsequently performed to investigate Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) enriched signaling pathways of these DEPs. Six proteins (AZU1, COX4I1, EDF1, KRT31, MMP12, and PRG2) were selected for further validation via enzyme-linked immunosorbent assay (ELISA).ResultsCompared with BM group and N group, HBM group had a higher whole CSF protein level (5.6 ± 2.7 vs. 1.7 ± 1.0 vs. 1.2 ± 0.5 g/l) and lower whole CSF glucose level (0.8 ± 0.6 vs. 1.8 ± 0.7 vs. 3.3 ± 0.8 mmol/l) (both P < 0.05). Over 300 DEPs were differentially expressed in HBM group compared with BM group and BM compared with N group, of which 78% were common to both. Cluster analysis indicated that the levels of 226 proteins were increased in BM group compared with N group and were decreased in HBM group compared with BM group. Bioinformatics analysis indicated the involvement of the cell adhesion, immune response and extracellular exosome signaling were significantly enriched in HBM compared with BM group and BM compared with N group. 267 DEPs were identified between HBM group with N group, KEGG analysis indicated that DEPs mainly involved in filament cytoskeleton and immune response. The ELISA results further verified that the expression levels of AZU1 were significantly different from among three groups (both P < 0.05).ConclusionThis is the first reported characterization of quantitative proteomics from the CSF of infants with HBM. Our study also demonstrated that AZU1 could be a potential biomarker for the diagnosis of hydrocephalus in bacterial meningitis.

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“…Streptococcus agalactiae, categorized in group B Streptococcus, is the most common microorganism causing purulent meningitis among neonates or infants younger than 90 days [124][125][126]. Figure 43 displays Gram-positive cocci phagocytized by neutrophils in the cerebrospinal fluid of a neonate.…”

Section: Purulent Meningitis In the Neonate Caused By Group B Strepto...mentioning

confidence: 99%

Pathology of Streptococcal Infections

Tsutsumi¹

2022

Antibiotic Resistance - New Insights [Working Title]

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Streptococcus pyogenes and Streptococcus pneumoniae, representative Gram-positive cocci, may cause both localized (skin and soft tissue) and systemic infections. Lobar pneumonia is a unique form of acute and severe lung infection of S. pneumoniae. Streptococcus viridans group, normal flora of the oral cavity, may lead not only to mucosal infection but also to aspiration pneumonia, infective endocarditis, and systemic infections. The severest and often lethal form of progressive and systemic infection includes fulminant streptococcal and pneumococcal infections. Autopsy is essentially important for the analysis of fulminant infections. Pathological features of varied streptococcal infections are illustrated and discussed. Immunohistochemical identification of the pathogen in formalin-fixed, paraffin-embedded sections is effective and valuable in confirming the type of infected pathogens.

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Group B Streptococcal Neonatal Meningitis

Cited by 39 publications

References 275 publications

Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics

Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics

Quantitative proteomics on the cerebrospinal fluid of hydrocephalus in neonatal bacterial meningitis

Pathology of Streptococcal Infections

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