Group B Streptococcus and Premature Rupture of Membranes and Preterm Delivery

Matorras, Roberto; Perea, Adela García; Omeñaca, F; Usandizaga, J. A.; Nieto, Anı́bal; Herruzo, Rafael

doi:10.1159/000293607

Cited by 46 publications

(25 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2,3 Although the majority of pregnant women remain asymptomatic, GBS colonization has been linked to certain obstetric complications, including chorioamnionitis and premature rupture of membranes. 4,5 Vertical transmission of maternal GBS is a leading cause of neonatal sepsis, pneumonia, and meningitis. Randomized clinical trials in the 1980s showed that intrapartum antibiotic prophylaxis can diminish the risk of neonatal GBS disease.…”

Section: Introductionmentioning

confidence: 99%

Group B Streptococcus Colonization by HIV Status in Pregnant Women: Prevalence and Risk Factors

Shah

Aziz

Leva

et al. 2011

Journal of Women's Health

View full text Add to dashboard Cite

HIV-1 infection is not a risk factor for GBS colonization among an ethnically diverse pregnant population at San Francisco General Hospital, although our data suggest that among HIV-infected women, plasma HIV-1 viremia may be associated with GBS colonization. Interventions that diminish HIV-1 plasma viral load and, perhaps, genital tract shedding of HIV may be associated with a reduced risk of GBS colonization in future studies.

show abstract

Section: Introductionmentioning

confidence: 99%

Group B Streptococcus Colonization by HIV Status in Pregnant Women: Prevalence and Risk Factors

Shah

Aziz

Leva

et al. 2011

Journal of Women's Health

View full text Add to dashboard Cite

show abstract

“…Infection of newborns exhibiting early-onset neonatal disease occurs via vertical transmission during passage through the birth canal or by exposure to infected amniotic fluid (1,17). Studies have correlated the incidence of early-onset neonatal disease as well as premature rupture of membranes with heavy GBS colonization of the vagina, cervix, and urine of pregnant women (1,10,11,13,15). A significant association has been shown between premature rupture of membranes and symptomatic early-onset neonatal disease (13,15).…”

mentioning

confidence: 99%

Cell-associated collagenolytic activity by group B streptococci

1994

View full text Add to dashboard Cite

Group B streptococci (GBS) are important pathogens in neonatal sepsis, pneumonia, and meningitis. The ability of GBS to invade the collagen-rich amniotic membrane of the placenta has been shown in vitro. In the presence of GBS, the collagen fibrils of the amnion appear disordered, suggesting a role for GBS in premature rupture of membranes. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Sephadex G-200 column chromatography, and gelatin zymograms were used in this study to characterize cell-associated collagenolytic activities of GBS. The synthetic peptide 2-furanacryloyl-Leu-Gly-Pro-Ala (FALGPA), which mimics the primary structure of collagen, was degraded by GBS USF704, a clinical isolate from the placenta of a septic newborn. Cells of GBS USF704 (9 x 107 CFU/ml) hydrolyzed 902 nmol of FALGPA over a 24-h period. As reported for zinc metalloenzymes such as collagenase, the hydrolysis of FALGPA by GBS was inhibited by addition of EDTA or 1,10-phenanthroline. Boiling of the cells resulted in loss of activity, while higher activity was observed with crude GBS cell lysates (hydrolysis of 970 nmol of FALGPA in 1.5 h). Antiserum raised against collagenase from Clostridium histolyticum was found to cross-react with cell-associated proteins produced by GBS and to inhibit GBS FALGPA hydrolysis. Twenty-five additional GBS clinical isolates were screened and found to have various levels of FALGPA hydrolytic activity. These observations suggest a cell-associated collagenolytic activity by GBS which may be involved in premature rupture of membranes and neonatal disease.

show abstract

“…GBS colonized in pregnant woman may cause preterm birth act, EMR and PMR (26) . However, in certain studies, it is reported that risk of development of EMR and PMR are not increased by GBS colonization (7,27) . In our study no significant association was detected between GBS colonization and EMR and PMR.…”

Section: Discussionmentioning

confidence: 98%

“…Although GBS infection may be asymptomatic in pregnant women, it may be appeared as asymptomatic bacteriuria, cystitis, pyelonephritis, endometritis, wound infection after cesarean section or episiotomy, puerperal sepsis, meningitis and thrombophlebitis with serious complications such as preterm birth act, early membrane rupture (EMR), prolonged membrane rupture (PMR) and chorioamnionitis (7) . Since it may cause serious infections, it is necessary to define basic strategies to prevent and treat GBS infections.…”

Section: Introductionmentioning

confidence: 99%