Group B streptococcus infection and diabetes: A review

Yanai, Hidekatsu; Hamasaki, Hidetaka; Tsuda, Naonori; Adachi, Hisashi; Yoshikawa, Reo; Moriyama, Sumie; Masui, Yoshinori; Mishima, Saori

doi:10.5897/jma11.088

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…These species were only found in select mice and at low levels (>10 2 CFU/g wound). These data support clinical findings that GBS establishes infection in the diabetic wound environment ( 19 , 39 ) and provide a relevant model for further investigation.…”

Section: Resultssupporting

confidence: 85%

“…These data support clinical findings that GBS establishes infection in the diabetic wound environment (19,39) and provide a relevant model for further investigation.…”

Section: Development Of a Murine Model Of Gbs Diabetic Wound Infectionsupporting

confidence: 85%

“…P. aeruginosa infection of chronic wounds has been linked to enhanced biofilm formation and activation of matrix metalloproteases that degrade extracellular matrix molecules (17,18). Conversely, GBS is rarely identified from nondiabetic wounds but is being increasingly identified in diabetic individuals (19,20). While some work has characterized S. aureus and P. aeruginosa in diabetic wound infections, no previous studies have investigated GBS pathogenesis in the diabetic wound or on the skin in general.…”

Section: Introductionmentioning

confidence: 99%

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Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment

et al. 2022

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Diabetic wounds have poor healing outcomes due to the presence of numerous pathogens and a dysregulated immune response. Group B Streptococcus (GBS) is commonly isolated from diabetic wound infections, but the mechanisms of GBS virulence during these infections have not been investigated. Here, we develop a murine model of GBS diabetic wound infection and, using dual RNA sequencing, demonstrate that GBS infection triggers an inflammatory response. GBS adapts to this hyperinflammatory environment by up-regulating virulence factors including those known to be regulated by the two-component system covRS , such as the surface protein pbsP , and the cyl operon, which is responsible for hemolysin/pigmentation production. We recover hyperpigmented/hemolytic GBS colonies from the murine diabetic wound, which we determined encode mutations in covR . We further demonstrate that GBS mutants in cylE and pbsP are attenuated in the diabetic wound. This foundational study provides insight into the pathogenesis of GBS diabetic wound infections.

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Section: Resultssupporting

confidence: 85%

“…These data support clinical findings that GBS establishes infection in the diabetic wound environment (19,39) and provide a relevant model for further investigation.…”

Section: Development Of a Murine Model Of Gbs Diabetic Wound Infectionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment

et al. 2022

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“…En los últimos años se ha observado un incremento de infecciones por SGB en pacientes adultos no gestantes. Éstas se presentan con mayor frecuencia en individuos mayores a 65 años o con alguna patología de base como diabetes (DBT), cáncer, alteraciones neurológicas y alcoholismo entre otras 7,8 . Con respecto a los síndromes clínicos causados por SGB en adultos no gestantes, el espectro de infección es bastante amplio prevaleciendo bacteriemia primaria seguida de infecciones de piel y partes blandas, osteoarticulares, urosepsis, infecciones abdominales y del tracto genital 9 .…”

Section: Introductionunclassified

Streptococcus agalactiae en adultos no gestantes. Análisis de 10 años en un Hospital Universitario

Cometto

Gasparotto²,

Navarro³

et al. 2018

Rev Fac Cien Med Univ Nac Cordoba

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ResumenIntroducción: Streptococcus agalactiae (SGB) es un reconocido patógeno asociado a infecciones en recién nacidos y lactantes pequeños, en mujeres gestantes y en puérperas. En los últimos años se ha observado un incremento de infecciones por este agente en pacientes adultos no gestantes, siendo más frecuentes en mayores de 65 años y con alguna comorbilidad.Métodos: estudio retrospectivo y observacional de muestras de pacientes adultos no gestantes analizadas en el laboratorio de Bacteriología del Hospital Nacional de Clínicas de la ciudad de Córdoba, desde enero de 2008 a diciembre de 2017. Se analizó edad y sexo de los pacientes, comorbilidades y tipo de muestra.Resultados: El total de muestras positivas fue de 187, 91 (49%) correspondieron a mujeres y 96 (51%) a varones. La edad media fue de 67 años. De las muestras, orina fue la prevalente con 90 aislamientos (48.1%), seguidas de sangre con 39 (20.8%) y piel y partes blandas con 38 (20.3%). De los 187 adultos, 177 (95%) presentaron al menos una comorbilidad, siendo la más frecuente diabetes, seguida de neoplasias. Sólo 10 (5%) no presentaron comorbilidades.Conclusión: Los hallazgos en nuestro trabajo, como así también los publicados por diversos autores, ponen en evidencia la necesidad de considerar a Streptococcus agalactiae no sólo un patógeno de neonatos y embarazadas, sino también de pacientes adultos mayores y con diferentes comorbilidades, en especial aquellos que padecen DBT o neoplasias.Palabras claves: Streptococcus agalactiae; infecciones estreptocócicas; inmunosupresión; bacteriemia; comorbilidad

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Triple threat: how diabetes results in worsened bacterial infections

Darwitz,

Genito,

Thurlow

2024

Infect Immun

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Diabetes mellitus, characterized by impaired insulin signaling, is associated with increased incidence and severity of infections. Various diabetes-related complications contribute to exacerbated bacterial infections, including hyperglycemia, innate immune cell dysfunction, and infection with antibiotic-resistant bacterial strains. One defining symptom of diabetes is hyperglycemia, resulting in elevated blood and tissue glucose concentrations. Glucose is the preferred carbon source of several bacterial pathogens, and hyperglycemia escalates bacterial growth and virulence. Hyperglycemia promotes specific mechanisms of bacterial virulence known to contribute to infection chronicity, including tissue adherence and biofilm formation. Foot infections are a significant source of morbidity in individuals with diabetes and consist of biofilm-associated polymicrobial communities. Bacteria perform complex interspecies behaviors conducive to their growth and virulence within biofilms, including metabolic cross-feeding and altered phenotypes more tolerant to antibiotic therapeutics. Moreover, the metabolic dysfunction caused by diabetes compromises immune cell function, resulting in immune suppression. Impaired insulin signaling induces aberrations in phagocytic cells, which are crucial mediators for controlling and resolving bacterial infections. These aberrancies encompass altered cytokine profiles, the migratory and chemotactic mechanisms of neutrophils, and the metabolic reprogramming required for the oxidative burst and subsequent generation of bactericidal free radicals. Furthermore, the immune suppression caused by diabetes and the polymicrobial nature of the diabetic infection microenvironment may promote the emergence of novel strains of multidrug-resistant bacterial pathogens. This review focuses on the “triple threat” linked to worsened bacterial infections in individuals with diabetes: (i) altered nutritional availability in diabetic tissues, (ii) diabetes-associated immune suppression, and (iii) antibiotic treatment failure.

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Group B streptococcus infection and diabetes: A review

Cited by 4 publications

References 27 publications

Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment

Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment

Streptococcus agalactiae en adultos no gestantes. Análisis de 10 años en un Hospital Universitario

Triple threat: how diabetes results in worsened bacterial infections

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