Group comparative trial of 2% sodium cromoglycate (Opticrom) with placebo in the treatment of seasonal allergic conjunctivitis

Lindsay-Miller, A. C. M.

doi:10.1111/j.1365-2222.1979.tb01553.x

Cited by 38 publications

(5 citation statements)

References 9 publications

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“…Sodium cromoglycate has been shown to be effective in various allergic disorders of the eye including SAC [7][8][9]. Sodium cromoglycate is a synthetic chromone compound of low toxicity.…”

Section: Discussionmentioning

confidence: 99%

Double‐blind group comparative study of 2% nedocromil sodium eye drops with 2% sodium cromoglycate and placebo eye drops in the treatment of seasonal allergic conjunctivitis

Leino

Ennevaara

Latvala

et al. 1992

Clin Experimental Allergy

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A 4 week, multicentre, double-blind, double dummy, placebo controlled group comparative study was carried out during the birch pollen season to compare the efficacy and tolerability of 2% nedocromil sodium eye drops (twice daily) and 2% sodium cromoglycate eye drops (four times daily). Participants with a history of seasonal allergic conjunctivitis (SAC) were randomized to receive nedocromil sodium (60), sodium cromoglycate (61) or placebo (64). Clinical assessment of SAC showed improvement with both active treatments compared to placebo but symptomatology was low and only changes in photophobia and grittiness reached significance (P < 0.05). Patient diaries showed significant control of itching by both active treatments, compared to placebo, with no differences between the active preparations. Patients' opinions indicated a marked placebo effect: 73% of this group reported full or moderate control of symptoms, compared with 75% in sodium cromoglycate and 80% in the nedocromil sodium group. Unusual symptoms were most common (27 patients) with nedocromil sodium eye drops: P < 0.05 vs. placebo (15 patients). There were no serious adverse events. Nedocromil sodium eye drops (b.d.) and sodium cromoglycate eye drops (q.i.d.) were both considered clinically more effective than placebo in controlling symptoms of SAC due to birch pollen.

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“…Sodium cromoglycate has been shown to be effective in various allergic disorders of the eye including SAC [7][8][9]. Sodium cromoglycate is a synthetic chromone compound of low toxicity.…”

Section: Discussionmentioning

confidence: 99%

Double‐blind group comparative study of 2% nedocromil sodium eye drops with 2% sodium cromoglycate and placebo eye drops in the treatment of seasonal allergic conjunctivitis

Leino

Ennevaara

Latvala

et al. 1992

Clin Experimental Allergy

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“…They do this by acting as a barrier to prevent allergen from attacking the conjunctival surface, helping to dilute allergen and mediators in the tear film, and acting as an eyewash. Such environmental studies are known to have placebo effect ratings as high as 50% and 60% [23,24]. Although it is difficult to completely eliminate, the placebo effect is a significant factor, and it can be expected to play a larger role in environmental studies in which it acts as an eyewash, compared with single-drop studies in the CAC model.…”

Section: Factors Affecting Data In the Environmental Modelmentioning

confidence: 97%

Conjunctival allergen challenge: Models in the investigation of ocular allergy

Abelson

Loeffler

2003

Curr Allergy Asthma Rep

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Recently, the number of agents to treat ocular allergy has increased dramatically, from three (pheniramine, antazoline, cromolyn) to more than a dozen. A general increase in the incidence of atopy in recent years and the fact that patients are becoming less tolerant of bothersome signs and symptoms have been driving forces in this increase. As visual tasking, such as reading and working on a computer, has become more prevalent, there is an increased awareness of ocular allergy and the impact it has on quality of life and productivity at work and school. With the need for more effective medications, the development of models, such as the conjunctival allergen challenge (CAC), has made the identification of new agents more efficient. In this article, we review the relevant background on the science behind allergen challenges in the eye, how models are designed, and how models are used in the field today.

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“…Although two studies showed equivalent efficacy of cromones and terfenadine, the efficacy of cromones in SAR has been questioned, especially when compared to topical corticosteroids and antihistamines ( 105, 123, 124). Comparisons between topical corticosteroids and DSCG or topical antihistamines and DSCG in patients with seasonal AR demonstrated the greater efficacy of both drugs over DSCG, for both symptom control and patient compliance (due to the multiple daily administration necessary for DSCG) ( 105, 122).…”

Section: Cromonesmentioning

confidence: 99%