Purpose-The purpose of this meta-analysis was to meet the need to quantify the influence of diabetes self-management training on quality of life (QOL) of adult diabetes patients.Methods-Extensive literature searching located published and unpublished diabetes selfmanagement intervention studies that measured QOL outcomes among at least 5 subjects with type 1 or 2 diabetes. Data were extracted from primary study reports which included interventions designed to improve diabetes self-management and adequate data to calculate effect sizes. Randomeffects meta-analytic procedures were used to estimate overall effects between treatment and control groups at outcome assessment and between baseline and outcome data for both treatment subjects and control subjects.Results-Exhaustive searching yielded 20 comparisons across 1,892 subjects. The comparisons between treatment and control group outcomes following interventions yielded an effect size of 0.281. The comparisons between treatment group at baseline and outcome measurement yielded an effect size of 0.312 to 0.313. Each of these effect sizes were statistically significant, meaning that the hypothesis that interventions to improve diabetes self-management results in increased QOL was supported. Control subjects did not experience improved QOL while participating in studies.Conclusion-These findings document that people with diabetes experience improved QOL from participation in diabetes self-management training programs. Future diabetes self-management intervention studies should include quality of life outcomes so that this important outcome can be further studied. After more primary studies are available future meta-analyses can explore important moderator analyses.Researchers and clinicians are increasingly considering the influence of diabetes care burden and complications on quality of life (QOL). QOL has been found to be lower in persons with diabetes when compared to individuals that do not have diabetes. 1, 2 Among adults with diabetes, QOL decreases over time despite improvements in clinical outcomes. 3 The importance of QOL has been recognized as an important outcome of diabetes care as well as a factor in sustaining the ongoing performance of diabetes self-care activities. 4 While QOL in diabetes patients has been studied in relation to patient demographics, type of diabetes and diabetes treatment, it historically has not routinely measured as part of diabetes self-management training clinical trials. Glasgow found that only 17% of diabetes selfmanagement training clinical trials reported in the late 1990's included a QOL outcome. 5 With the increased attention to QOL outcomes, researchers have begun reporting this important outcome in intervention trials.Correspondence to: Vicki S. Conn, conn@missouri.edu. The final version of this paper has been published in The Diabetes Education, 34, 815-823, 2008 8 None of the previous reviews have conducted a quantitative synthesis using meta-analysis. The purpose of this study was to meet the need to quanti...