This paper explores further the computation of the twisted K-theory and K-homology of compact simple Lie groups, previously studied by Hopkins, Moore, Maldacena-Moore-Seiberg, Braun, and Douglas, with a focus on groups of rank 2. We give a new method of computation based on the Segal spectral sequence which seems to us appreciably simpler than the methods used previously, at least in many key cases.2010 Mathematics Subject Classification. Primary 19L50. Secondary 81T30, 57T10, 55T15, 55R20.