Group G Streptococcal Infections

Rolston, Kenneth V. I.

doi:10.1001/archinte.1986.00360170053003

Cited by 33 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…equisimilis (group G streptococcus [GGS]) commonly inhabits the throat, skin, and vagina of healthy humans (28). However, occasionally the organism can cause pharyngitis, impetigo, cellulitis, septicemia, glomerulonephritis, and toxic shock (14,28). This same disease spectrum generally coincides with that of a well-known human pathogen, the group A streptococcus (GAS; Streptococcus pyogenes) which cohabits the same tissue sites.…”

Section: Streptococcus Dysgalactiae Subsp Equisimilis Strains (Groupmentioning

confidence: 94%

Phage 3396 from a Streptococcus dysgalactiae subsp. equisimilis Pathovar May Have Its Origins in Streptococcus pyogenes

et al. 2007

View full text Add to dashboard Cite

Streptococcus dysgalactiae subsp. equisimilis strains (group G streptococcus [GGS]) are largely defined as commensal organisms, which are closely related to the well-defined human pathogen, the group A streptococcus (GAS). While lateral gene transfers are emerging as a common theme in these species, little is known about the mechanisms and role of these transfers and their effect on the population structure of streptococci in nature. It is now becoming evident that bacteriophages are major contributors to the genotypic diversity of GAS and, consequently, are pivotal to the GAS strain structure. Furthermore, bacteriophages are strongly associated with altering the pathogenic potential of GAS. In contrast, little is know about phages from GGS and their role in the population dynamics of GGS. In this study we report the first complete genome sequence of a GGS phage, ⌽3396. Exhibiting high homology to the GAS phage ⌽315.1, the chimeric nature of ⌽3396 is unraveled to reveal evidence of extensive ongoing genetic diversity and dissemination of streptococcal phages in nature. Furthermore, we expand on our recent findings to identify inducible ⌽3396 homologues in GAS from a region of endemicity for GAS and GGS infection. Together, these findings provide new insights into not only the population structure of GGS but also the overall population structure of the streptococcal genus and the emergence of pathogenic variants.Streptococcus dysgalactiae subsp. equisimilis (group G streptococcus [GGS]) commonly inhabits the throat, skin, and vagina of healthy humans (28). However, occasionally the organism can cause pharyngitis, impetigo, cellulitis, septicemia, glomerulonephritis, and toxic shock (14,28). This same disease spectrum generally coincides with that of a well-known human pathogen, the group A streptococcus (GAS; Streptococcus pyogenes) which cohabits the same tissue sites. Due to the extensive overlap of the disease spectrum of GGS with that caused by GAS, it is possible that disease burden specifically attributed to GGS has been historically underestimated. Of late, there are reported increases of GGS infections associated with classic human GAS-associated diseases, including invasive manifestations (10,14,15,19,23,34).Phylogenetic analyses based on rRNA sequence and other molecular clocks revealed that S. dysgalactiae spp. are closely related to S. pyogenes (16,26,35,38). The observations of overlapping clinical presentations, niche-sharing for colonization, and this evolutionary relatedness are conducive for interspecies lateral genetic transfers (LGT). Previous studies have shown that GGS possesses genes for M protein, C5a peptidase, streptokinase, streptococcal pyrogenic exotoxins, and fibronectin binding proteins (9,20,21,24,25,29,37,40). These are well defined as essential virulence determinants in GAS. The presence of mosaic structures among some of these genes within GAS and GGS strongly suggests that interspecies LGT events do indeed occur between these two streptococci and could be derived from recent and...

show abstract

Section: Streptococcus Dysgalactiae Subsp Equisimilis Strains (Groupmentioning

confidence: 94%

Phage 3396 from a Streptococcus dysgalactiae subsp. equisimilis Pathovar May Have Its Origins in Streptococcus pyogenes

et al. 2007

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…equisimilis (group G beta-haemolytic streptococcus [GGS]) commonly inhabits the throat, skin, and vagina of healthy humans [1]. However, occasionally, the organism can cause pharyngitis, impetigo, cellulitis, septicemia, glomerulonephritis, and toxic shock [1]. The same disease spectrum generally coincides with that of a well-known human pathogen, the group A beta-haemolytic Streptococcus (GAS; Streptococcus pyogenes) which cohabits the same tissue sites.…”

Section: Introductionmentioning

confidence: 99%

Post-operative ocular infection due to Streptococcus dysgalactiae subspecies equisimilis

Kaliamurthy

Cuteri

Jesudasen

et al. 2011

J Infect Dev Ctries

View full text Add to dashboard Cite

Ocular infections due to Streptococcus dysgalactiae subsp. equisimilis are rare. In the present report, three patients with a history of uncomplicated small incision cataract surgery with intraocular lens implantation developed exogenous endophthalmitis due to Streptococcus dysgalactiae subsp. equisimilis. The identification of the organisms was confirmed by PCR for a 16S rRNA sequence specific to the species S. dysgalactiae. Intravitreal treatment of cefazolin and amikacin, in addition to topical ofloxacin and tobramycin, resulted in resolution of infection in all three patients. Our reports indicate the importance of bacterial culture and molecular identification in the diagnosis of S. dysgalactiae subsp. equisimilis infection in the eye.

show abstract

“…Penicillin G, with or without an aminoglycoside for synergistic efficacy, has been the cornerstone of treatment for such infections (9,16,17). However, the usefulness of treatment with penicillin G in patients with such infections may be limited by adverse drug reactions or by P-lactam tolerance on the part of the infecting strain (14). There is limited experience in vivo with nonpenicillin antibiotic regimens in treating serious group G streptococcal infections.…”

mentioning

confidence: 99%

LY146032 compared with penicillin G in experimental aortic valve endocarditis caused by group G streptococci

Bayer

Yih

Hirano

1988

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Rabbits with group G streptococcal aortic endocarditis received no therapy (controls); repeated doses of procaine penicillin G, 300 mg/kg (body weight) per day, administered intramuscularly; or LY146032, a new peptolide antibiotic, 20 mg/kg per day, administered intravenously. Penicillin G and LY146032 reduced mean intravegetation group G streptococcal densities significantly below those observed in controls at both day 3 and day 6 of therapy. Penicillin G effected a more rapid clearance of intravegetation streptococci than LY146032 by day 3, but not by day 6, of therapy.

show abstract

Group G Streptococcal Infections

Cited by 33 publications

References 15 publications

Phage 3396 from a Streptococcus dysgalactiae subsp. equisimilis Pathovar May Have Its Origins in Streptococcus pyogenes

Phage 3396 from a Streptococcus dysgalactiae subsp. equisimilis Pathovar May Have Its Origins in Streptococcus pyogenes

Post-operative ocular infection due to Streptococcus dysgalactiae subspecies equisimilis

LY146032 compared with penicillin G in experimental aortic valve endocarditis caused by group G streptococci

Contact Info

Product

Resources

About