To effectively ensure the operational safety of an electric vehicle with in-wheel motor drive, a novel diagnosis method is proposed to monitor each in-wheel motor fault, the creativity of which lies in two aspects. One aspect is that affinity propagation (AP) is introduced into a minimum-distance discriminant projection (MDP) algorithm to propose a new dimension reduction algorithm, which is defined as APMDP. APMDP not only gathers the intra-class and inter-class information of high-dimensional data but also obtains information on the spatial structure. Another aspect is that multi-class support vector data description (SVDD) is improved using the Weibull kernel function, and its classification judgment rule is modified into a minimum distance from the intra-class cluster center. Finally, in-wheel motors with typical bearing faults are customized to collect vibration signals under four operating conditions, respectively, to verify the effectiveness of the proposed method. The results show that the APMDP’s performance is better than traditional dimension reduction methods, and the divisibility is improved by at least 8.35% over the LDA, MDP, and LPP. A multi-class SVDD classifier based on the Weibull kernel function has high classification accuracy and strong robustness, and the classification accuracies of the in-wheel motor faults in each condition are over 95%, which is higher than the polynomial and Gaussian kernel function.