Grover's disease associated with Sarcoptes scabiei: case report

Grover’s disease: a rare bullous dermatosis spontaneously regressing

“…Vesiculopustular, bullous, follicular, herpetiformis, and erythematous forms have already been described. 1,2 The most common locations of eruptions are the chest and root of members, while scalp, face, and neck are less affected. In an exacerbation, the erythematous papules may converge, forming erythematous plaques as it is the case of our patient.…”

“…The age group most affected by GD includes individuals over the fifth decade in age, with predominance of the Caucasian ethnicity, and with a men to women ratio of 3:1. 2 The etiology of GD is still unclear, but many factors have been associated with the development of the disease. 1 Fever or prolonged bed rest, sweating or excessive heat, exposure to UV radiation, treatment with ionizing radiations, xerosis and some drugs have been associated with this disease.…”

“…4 The GD is an under-diagnosed disease, probably due to the large number of oligosymptomatic cases and/or transient or due to the fact that the disease clinically co-exists or is confused with other illnesses making diagnosis difficult. 2 The clinical differential diagnosis of Grover's disease includes a variety of skin disorders such as pemphigus foliaceus, pemphigus vulgaris, impetigo, dermatitis herpetiformis, Hailey-Hailey disease and Darier's disease. Four histological patterns have been identified: Darier type, Haley-Haley type, pemphigus and spongiotic type.…”

“…5 In the case of our patient, the biopsy and histopathological examination of two skin segments showed findings compatible with pemphigus like forms, and Hailey-Hailey-simile. 2 Histopathology examination represents the gold standard for the diagnosis. In the Darier-like variety, which represents the most frequent pattern seen in Grover's disease.…”

“…It is important, also, to minimize skin irritation by using mild soaps, light-colored cotton fabrics, and adequate hydration. 2 Topical therapy consists of steroids, tretinoin, and calcipotriol. Systemic therapy includes oral vitamine A, corticosteroids and lactic acid.…”