Grover’s Disease Induced by Cetuximab

Tscharner, Gion G.; Bühler, Sabine; Borner, Markus; Hunziker, Thomas

doi:10.1159/000092836

Cited by 29 publications

(13 citation statements)

References 27 publications

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“…Quite recently, a case of cetuximab-induced GD was reported in an oncologic patient [13]. Our patient received chemotherapy eleven years prior GD onset and has recorded no NHL relapse to date.…”

Section: Discussionmentioning

confidence: 87%

Grover's Disease after Heart Transplantation: A Case Report

Ippoliti

Paulli

Lucioni

et al. 2012

Case Reports in Transplantation

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Grover's disease is a transient acantholytic dermatosis of unknown cause, manifesting clinically as a papular skin eruption that is usually located on the anterior chest and abdomen. Histologically characterized by an acantholytic pattern, it has been associated with numerous disorders, including hematologic malignancies, chronic renal failure, and HIV infection, as well as with chemotherapy and bone marrow and/or kidney transplant. Evaluation of followup and treatment is often complicated by spontaneous remission and the occasionally fluctuant course of the disease. Here we report the case of a patient with sudden onset of Grover's disease after heart transplantation. To the best of our knowledge, this is the first observation of Grover's disease as diagnosed after heart transplantation.

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Section: Discussionmentioning

confidence: 87%

Grover's Disease after Heart Transplantation: A Case Report

Ippoliti

Paulli

Lucioni

et al. 2012

Case Reports in Transplantation

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“…A single case of transient acantholytic dermatosis during cetuximab therapy is reported in the literature. 60 …”

Section: Epidermal Growth Factor Receptor Inhibitorsmentioning

confidence: 99%

Chemotherapeutic agents and the skin: An update

Heidary

Naik

Burgin

2008

Journal of the American Academy of Dermatology

224

138

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“…Skin lesions are typically polymorphous in the form of papulovesicles or smooth light erythematous or brownish papules, with crusts or keratotic surface, in nummular, herpetiform or zosteriform distribution or may confluent into plaques [4]. The skin lesions mainly affect the trunk and the back, upper extremities and thighs, but may also have an atypical extensive presentation especially in patients suffering from malignancy, during the course of oncologic treatment or in transplants [11][12][13][14][15][16][17][18][19][20]. Given that Grover's disease has been shown to be associated with hematological or visceral malignancies, it is of the utmost importance to examine the patient in that direction as well [4].…”

Section: Discussionmentioning

confidence: 99%

Grover’s disease in a patient with atopic dermatitis - a case report

et al. 2021

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Introduction. Grover?s disease is characterized by pruriginous polymorphic rash with a variable course and duration. Although the etiology is still unknown, the disease is often associated with other dermatoses, malignant diseases, use of certain medications, as well as immunosuppression. Case Report. We report a case of a 70-year-old male patient who was referred for examination to the Clinic of Dermatovenereology Diseases, Clinical Center of Vojvodina, due to a rash that lasted for nine months. The first lesions on the skin appeared around the nipples as exudative eczematous plaques. A few months later, identical lesions appeared on the lower legs. During treatment with systemic antihistamines and topical corticosteroids, there were episodes of transient improvements and re-exacerbations. In the meantime, erythematous brownish, round and oval papules appeared on the abdomen and the back, accompanied by intense itch. Laboratory findings revealed eosinophilia and elevated serum immunoglobulin E levels. A skin biopsy of the back lesion was performed and the histopathological examination confirmed the diagnosis of Grover?s disease. After the systemic treatment using corticosteroids and antihistamines, with gradual dose reduction and application of topical corticosteroids and emollients, complete regression of the skin lesions was achieved. Conclusion. Since the clinical manifestations of the disease may be nonspecific and discrete, dermatopathological analysis is of crucial importance in making the correct diagnosis. In patients with atopy, the treatment with systemic corticosteroids, antihistamines and topical agents may lead to regression of skin lesions with a significant improvement in the quality of life.

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Grover’s Disease Induced by Cetuximab

Cited by 29 publications

References 27 publications

Grover's Disease after Heart Transplantation: A Case Report

Grover's Disease after Heart Transplantation: A Case Report

Chemotherapeutic agents and the skin: An update

Grover’s disease in a patient with atopic dermatitis - a case report

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