Growing Heart Valve Implants for Children

Konsek, Haley; Sherard, Curry; Bisbee, Cora; Kang, Lillian; Turek, Joseph W.; Rajab, Taufiek Konrad

doi:10.3390/jcdd10040148

Cited by 9 publications

(8 citation statements)

References 65 publications

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“…A pHT is a potential procedure that is of interest to treat congenital heart diseases involving the recovery and transplantation of a donor heart valve [8]. Typically, congenital heart diseases require either a full, deceased donor heart transplant, or a valve replacement with either a mechanical valve or a bioprosthetic cadaveric tissue valve homograft.…”

Section: Discussionmentioning

confidence: 99%

“…In this ambiguous milieu, and with the recent introduction of a partial heart transplantation (pHT), it is of value to discuss the mechanism of CIT and WIT and how it may influence outcomes for a pHT. This paper aims to discuss the physiological basis of cellular damage due to CIT, CIT variation among different organs, and how CIT/WIT may play an important role in the value of a pHT and procurement of heart valves [8].…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations

et al. 2023

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Cold preservation is a key component to organ procurement and transplantation. Cold preservation functions by slowing metabolic activity of procured organs and begins the period known as cold ischemic time (CIT). Reducing CIT and warm ischemic time (WIT) are paramount to minimizing donor organ damage from ischemia and the build-up of waste products and signals that drive reperfusion injury prior to transplantation into a matching recipient. Preventing damage from CIT and WIT and extending the amount of time that organs can tolerate has been a major goal of organ transplantation since donors and recipients are frequently not located within the same hospital, region, or state. Meanwhile, the amount of CIT that a transplant center is willing to accept differs based on the organ, the institution receiving the organ offer, and the doctor receiving the offer for that institution. With the introduction of a partial heart transplantation conducted last year at Duke University, it is important to discuss how much CIT transplant centers conducting a partial heart transplantation (pHT) are willing to accept. This article will review the physiology of WIT and CIT, associated organ damage, CIT variation among transplant centers and organ types, and provide a brief discussion of the future of pHT-accepted CIT and the need for research in this field.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations

et al. 2023

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“…Despite an intensive research effort involving myriad cell types, scaffolds and strategies for cellularizing the scaffolds, all tissue engineering approaches to develop growing heart valve implants have failed in clinical translation. 17,19,20,21,22,23 Similar issues have plagued other applications for tissue engineering, such as attempts to create an artificial trachea. 24,25 This has resulted in some of the biggest biomedical research scandals of our time, including the Paolo Macchiarini scandal.…”

Section: Tissue-engineered Heart Valve Implantsmentioning

confidence: 99%

“…16 Growing heart valve implants would improve morbidity and mortality by avoiding the need to attempt complex valve repairs and by decreasing future reinterventions. 17…”

mentioning

confidence: 99%

Partial heart transplantation: Growing heart valve implants for children

Rajab

2023

Artificial Organs

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Heart valves serve a vital hemodynamic function to ensure unidirectional blood flow. Additionally, native heart valves serve biological functions such as growth and self‐repair. Heart valve implants mimic the hemodynamic function of native heart valves, but are unable to fulfill their biological functions. We developed partial heart transplantation to deliver heart valve implants that fulfill all functions of native heart valves. This is particularly advantageous for children, who require growing heart valve implants. This invited review outlines the past, present and future of partial heart transplantation.

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“…Bioprosthetic heart valves can overcome some of the limitations of mechanical heart valves, but their durability is limited to 10–15 years, making them unsuitable for younger patients [ 4 , 5 ]. In pediatric patients, both types of valve prostheses require frequent resizing surgeries due to their inability to remodel and adapt to growth [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Shear Stress Quantification in Tissue Engineering Bioreactor Heart Valves: A Computational Approach

Dave,

Luraghi,

Sierad

et al. 2024

JFB

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Tissue-engineered heart valves can grow, repair, and remodel after implantation, presenting a more favorable long-term solution compared to mechanical and porcine valves. Achieving functional engineered valve tissue requires the maturation of human cells seeded onto valve scaffolds under favorable growth conditions in bioreactors. The mechanical stress and strain on developing valve tissue caused by different pressure and flow conditions in bioreactors are currently unknown. The aim of this study is to quantify the wall shear stress (WSS) magnitude in heart valve prostheses under different valve geometries and bioreactor flow rates. To achieve this, this study used fluid–structure interaction simulations to obtain the valve’s opening geometries during the systolic phase. These geometries were then used in computational fluid dynamics simulations with refined near-wall mesh elements and ranges of prescribed inlet flow rates. The data obtained included histograms and regression curves that characterized the distribution, peak, and median WSS for various flow rates and valve opening configurations. This study also found that the upper region of the valve near the commissures experienced higher WSS magnitudes than the rest of the valve.

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Growing Heart Valve Implants for Children

Cited by 9 publications

References 65 publications

Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations

Mechanisms of Cold Preservation and Reperfusion Injury for Solid Organ Transplantation: Implications for Partial Heart Transplantations

Partial heart transplantation: Growing heart valve implants for children

Shear Stress Quantification in Tissue Engineering Bioreactor Heart Valves: A Computational Approach

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