Growing Teratoma Syndrome

Ganesan, Raji; Hirschowitz, Lynn

doi:10.1097/pgp.0000000000000180

Cited by 18 publications

(4 citation statements)

References 30 publications

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“…After surgery and chemotherapy, the immature tissue may transfer into mature tissue. Chemotherapeutic retroconversion has also been called growing teratoma syndrome (GTS) [ 19 ]. However, there are some differences between GP and GTS.…”

Section: Discussionmentioning

confidence: 99%

Gliomatosis peritonei: a series of eight cases and review of the literature

et al. 2016

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BackgroundGliomatosis peritonei (GP) is a rare condition characterized by mature glial tissue implants widespread in the peritoneum. The GP is often associated with ovarian teratoma. However, little is known about the characteristics and prognosis of GP. The purpose of this study was to describe the features, treatment, and prognosis of GP. Additionally, we review previously reported cases of GP, summarizing the presently known data.MethodsFrom January 2000 to January 2016, cases of ovarian teratoma and GP treated at Peking Union Medical College Hospital were reviewed. We assessed the pathology, treatments, and outcomes along with prognostic information. Additionally, the literature regarding this clinical condition was also reviewed.ResultsEight patients met the inclusion criteria. Patients had a median age of 20 (range, 15–25) years. GP was diagnosed as the primary tumor in 6 patients and at a secondary surgery in two patients. The primary ovarian tumor consisted of immature teratoma (n = 7) and mature teratoma (n = 1). Grades of immature ovarian teratoma were 2, grade 1; 3, grade 2; and 2, grade 3. Tumors mean had a size of 20.4 (range, 11–30) cm. The median follow-up time was 60.5 (range, 3–144) months. All cases had conservative surgery and seven of them had macroscopic residual disease postoperatively. During the study period, the eight patients remained alive and asymptomatic. Three patients in the study experienced spontaneous pregnancy. After reviewing the existing literature, a total of 14 patients with nodal gliomatosis were present and 10 of them were alive. According to the literature review, five articles reported more than five cases. Of a total of 67 patients, 60 of them remained alive.ConclusionThe prognosis of immature ovarian teratoma with GP is favorable. Complete resection of GP is often difficult. Residual peritoneal disease in GP can be asymptomatic and quiescent over a long period. A more conservative surgical approach may be carried out in patients with massive peritoneal spread after the presence of metastatic immature elements is excluded. Owing to the risk of recurrence and malignant transformation of GP, a long-term follow-up is necessary for patients with residual peritoneal disease.

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Section: Discussionmentioning

confidence: 99%

Gliomatosis peritonei: a series of eight cases and review of the literature

et al. 2016

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“…GP is a rare histological entity. It has been described in relationship to immature teratomas and growing teratoma syndrome (GTS) (Merard et al, 2015). GTS is defined as the presence of growing mature teratoma during or after completion of chemotherapy for a malignant germ cell tumour.…”

Section: Discussionmentioning

confidence: 99%

18F FDG positron-emission tomography findings of gliomatosis peritonei: A case report and review of the literature

Lavoie

Lacroix-Poisson

Hoang

et al. 2017

Gynecologic Oncology Reports

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“…Immature ovarian teratoma is a rare germ cell neoplasm that comprises <1% of ovarian teratomas [5]. The immature ovarian teratoma must be distinguished from the common benign mature teratoma (dermoid cyst).…”

Section: Discussionmentioning

confidence: 99%

Pediatric Ovarian Growing Teratoma Syndrome

Rentea

Varghese

Ahmed

et al. 2017

Case Reports in Surgery

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Ovarian immature teratoma is a germ cell tumor that comprises less than 1% of ovarian cancers and is treated with surgical debulking and chemotherapy depending on stage. Growing teratoma syndrome (GTS) is the phenomenon of the growth of mature teratoma elements with normal tumor markers during or following chemotherapy for treatment of a malignant germ cell tumor. These tumors are associated with significant morbidity and mortality due to invasive and compressive growth as well as potential for malignant transformation. Current treatment modality is surgical resection. We discuss a 12-year-old female who presented following resection of a pure ovarian immature teratoma (grade 3, FIGO stage IIIC). Following chemotherapy and resection of a pelvic/liver recurrence demonstrating mature teratoma, she underwent molecular genetics based chemotherapeutic treatment. No standardized management protocol has been established for the treatment of GTS. The effect of chemotherapeutic agents for decreasing the volume of and prevention of expansion is unknown. We review in detail the history, diagnostic algorithm, and previous reported pediatric cases as well as treatment options for pediatric patients with GTS.

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Growing Teratoma Syndrome

Cited by 18 publications

References 30 publications

Gliomatosis peritonei: a series of eight cases and review of the literature

Gliomatosis peritonei: a series of eight cases and review of the literature

18F FDG positron-emission tomography findings of gliomatosis peritonei: A case report and review of the literature

Pediatric Ovarian Growing Teratoma Syndrome

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