Growth and Biochemical Markers of Growth in Children With Snoring and Obstructive Sleep Apnea

Nieminen, Peter; Löppönen, Tuija; Tolonen, U.; Lanning, P; Knip, Mikael; Löppönen, Heikki

doi:10.1542/peds.109.4.e55

Cited by 226 publications

(175 citation statements)

References 41 publications

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“…It is possible that sleep-related problems are discussed during the medical visit; however they are not Clinical manifestations found in this study are in agreement with literature data. The complaints that motivated the polysomnographic studies were mainly restless sleep, snoring, breathing breaks during sleep and labored breathing 4,21,23 . It was seen that breathing difficulty during sleep was an important symptom indicative of OSHAS, being more significant in children younger than 5 years of age.…”

Section: Discussionmentioning

confidence: 99%

SAHOS em crianças: perfil clínico e respiratório polissonográfico

Ramos¹,

Daltro

Gregório³

et al. 2006

Rev. Bras. Otorrinolaringol.

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Obst ructive sleep apnea and hypopnea syndrome in children (osas) has an estimated prevalence of up to 3% and can be associated with neurocognitive and behavioural abnormalities, and also cardiovascular complications. This study may help pediatricians, who are unaware of the problem, to recognize osas. Study design: series of cases. Aim: to describe the clinical characteristics and polysomnographic respiratory findings in a population of children with obstructive sleep apnea and hypopnea syndrome referred to the sleep laboratory from january 2002 up to july 2003. Methods: we studied 93 patients between 2 and 10 years of age with polysomnographic diagnosis of obstructive sleep apnea and hypopnea syndrome. Age, gender, racial group and questions about the children's health and sleep related disorders were evaluated. Apneahypopnea index, oxyhemoglobin desaturation, and arousal index were evaluated too. Results: males represented 61.3%, With a mean age of 5.2 ± 2.1 (Years-old). The complaints that most commonly lead to the exams were snoring in 24.7% And restless sleep in 24.7%. Associated medical conditions frequently reported were allergic rhinitis (98.9%) And adenoid hypertrophy (50.6%). Mild apnea was found in 66%. The mean and sd of spo2 nadir was 89.1 ± 3.5% And the mean and sd of the number of arousals was 8.4 ± 3.5/ Hour of sleep. Conclusion: the results suggest the possibility that obstructive sleep apnea and hypopnea syndrome should be suspected in children with allergic diseases and adenoid and tonsil hypertrophy with snoring and restless sleep complaints.

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Section: Discussionmentioning

confidence: 99%

SAHOS em crianças: perfil clínico e respiratório polissonográfico

Ramos¹,

Daltro

Gregório³

et al. 2006

Rev. Bras. Otorrinolaringol.

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“…[1][2][3][4][5] Adenotonsillar hypertrophy is the primary cause of OSAS in children, and is usually treated with adenotonsillectomy (AT). AT has been reported to accelerate weight [6][7][8][9][10][11][12][13][14] in children with baseline failure to thrive (FTT), 1,3,4,15 normal weight patients, 9,11,14,[16][17][18][19][20] obese individuals, 9,13,16,21,22 and infants. 10 The majority of studies also have demonstrated an increase in the height growth rate after AT for OSAS, 3,6,11,17,23,24 but other studies reported no significant differences.…”

Section: (Continued On Last Page)mentioning

confidence: 99%

Growth After Adenotonsillectomy for Obstructive Sleep Apnea: An RCT

et al. 2014

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BACKGROUND AND OBJECTIVES: Adenotonsillectomy for obstructive sleep apnea syndrome (OSAS) may lead to weight gain, which can have deleterious health effects when leading to obesity. However, previous data have been from nonrandomized uncontrolled studies, limiting inferences. This study examined the anthropometric changes over a 7-month interval in a randomized controlled trial of adenotonsillectomy for OSAS, the Childhood Adenotonsillectomy Trial. METHODS: A total of 464 children who had OSAS (average apnea/hypopnea index [AHI] 5.1/hour), aged 5 to 9.9 years, were randomized to Early Adenotonsillectomy (eAT) or Watchful Waiting and Supportive Care (WWSC). Polysomnography and anthropometry were performed at baseline and 7-month follow-up. Multivariable regression modeling was used to predict the change in weight and growth indices. RESULTS: Interval increases in the BMI z score (0.13 vs 0.31) was observed in both the WWSC and eAT intervention arms, respectively, but were greater with eAT (P < .0001). Statistical modeling showed that BMI z score increased significantly more in association with eAT after considering the influences of baseline weight and AHI. A greater proportion of overweight children randomized to eAT compared with WWSC developed obesity over the 7-month interval (52% vs 21%; P < .05). Race, gender, and follow-up AHI were not significantly associated with BMI z score change. CONCLUSIONS: eAT for OSAS in children results in clinically significant greater than expected weight gain, even in children overweight at baseline. The increase in adiposity in overweight children places them at further risk for OSAS and the adverse consequences of obesity. Monitoring weight, nutritional counseling, and encouragement of physical activity should be considered after eAT for OSAS.

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“…[1][2][3] Significant complications of untreated OSA include learning difficulties. [4][5][6][7] behavioral problems, 8,9 failure to thrive, 10,11 pulmonary hypertension [12][13][14][15] and systemic hypertension. 16,17 Early diagnosis can decrease morbidity, 16 however the diagnosis of OSA is often delayed by months to years because of inadequate screening.…”

Section: Introductionmentioning

confidence: 99%

Inter‐ and intra‐rater reliability of neck circumference measurements in children

LaBerge

Vaccani

Gow

et al. 2008

Pediatric Pulmonology

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Summary. Rationale: Increased neck circumference is a risk factor for obstructive sleep apnea in adults. With rising obesity prevalence in children, it may be an important identifier of obstructive sleep apnea in children. The reliability of measuring neck circumference in children has not been systematically evaluated. Objective: To determine the inter-and intra-rater reliability of neck circumference measurements in children aged 2-16 years. Methods: Children aged 2-16 years with limb fractures were recruited. Neck circumference was measured by three investigators each using two separate unmarked paper tapes in the 2-5 year age group (N ¼ 43), and three separate tapes in the 6-10 and 11-16 year age groups (N ¼ 18 and 40). Results: Neck circumference measurements showed excellent inter-rater reliability for children 6-10 and 11-16 years (ICC ¼ 0.952 and 0.989). Substantial variation was observed for the 2-5 year age group (ICC ¼ 0.701). Good intra-rater reliability was demonstrated for the three groups (ICC range: 0.776, 0.950). Repeatability coefficients were 2.5-3.4 cm in the youngest age group and were 1.2-1.4 cm in the 6-16 year age group. Conclusion: In children 6-16 years old, neck circumference shows very good inter and good intra-rater reliability. Multiple measurements are not required for precision and reliability.

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Growth and Biochemical Markers of Growth in Children With Snoring and Obstructive Sleep Apnea

Cited by 226 publications

References 41 publications

SAHOS em crianças: perfil clínico e respiratório polissonográfico

SAHOS em crianças: perfil clínico e respiratório polissonográfico

Growth After Adenotonsillectomy for Obstructive Sleep Apnea: An RCT

Inter‐ and intra‐rater reliability of neck circumference measurements in children

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